Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference

Table 2 Test performance according to statistical methods by features

Features and test	Obuchowski weighted AUROC mean (standard error)	Standard binary AUROC mean (95%CI)
Fibrosis	5 stages, 10 comparisons	F2, F3, F4 vs F0, F1	F3, F4 vs F0, F1, F2	F4 vs F0, F1, F2, F3
FibroTest	0.919 (0.014)	0.83 (0.73-0.90)	0.83 (0.73-0.90)	0.80 (0.68-0.88)
VCTE	0.933 (0.014)	0.86 (0.77-0.92)	0.87 (0.78-0.93)	0.87 (0.78-0.94)
FIB-4	0.882 (0.019)	0.71 (0.60-0.80)	0.75 (0.63-0.83)	0.80 (0.67-0.89)
Activity	4 stages, 8 comparisons	A2, A3 vs A0, A1	-	-
ActiTest	0.921 (0.016)	0.86 (0.76-0.92)	-	-
ALT	0.905 (0.019)	0.83 (0.73-0.90)	-	-

AUROC: Areas under the receiver operating characteristic curve; CI: Confidence interval; VCTE: Vibration-controlled transient elastography; FIB-4: Fibrosis-4 index; ALT: Alanine aminotransferase.