Diagnostic performance of FibroTest-ActiTest, transient elastography, and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference

Table 1 Characteristics of participants

Characteristics	Included patients (n = 103)
Demographic
Age (years), median (IQR)	53 (38-61)
Female	86 (83)
BMI, median (IQR)	26 (21-28)
Baseline histological features (METAVIR)
Biopsy specimen length (mm), median (IQR)	12 (11-15)
F0	10 (10)
F1	28 (27)
F2	21 (20)
F3	24 (23)
F4	20 (19)
Fibrosis ≥ F2	65 (63)
Fibrosis ≥ F3	44 (43)
Cirrhosis F4	20 (19)
A0	10 (10)
A1	30 (29)
A2	42 (41)
A3	21 (20)
Activity ≥ A2	63 (61)
Steatosis > 0	12 (12)
Biopsy diagnosis
AIH	83 (81)
AIH and MASLD	1 (1)
AIH and PBC	19 (18)
NITs for significant fibrosis (≥ F2)
FibroTest > 0.48	55 (53)
FIB-4 ≥ 1.3	66 (64)
VCTE ≥ 8 kPa	61 (59)
NITs for advanced activity (≥ A2)
ActiTest > 0.52	48 (47)
ALT ≥ 50	63 (61)
Other serum components, median (IQR)
ALT (IU/L)	67 (37-160)
AST (IU/L)	52 (34-117)
GGT (IU/L)	73 (31-170)
Total bilirubin, μmol/L	16.7 (11-25)
Apolipoprotein-A1 (g/L)	1.57 (1.25-1.80)
Haptoglobin (g/L)	0.58 (0.56-1.30)
Alpha-2 macroglobulin (g/L)	2.34 (1.93-2.88)
Platelets (g/L)	201 (156-266)

Data presented as n (%). IQR: Interquartile range; BMI: Body mass index; METAVIR: Meta-analysis of Histological Data in Viral Hepatitis; AIH: Autoimmune hepatitis; MASLD: Metabolic dysfunction-associated steatotic liver disease; PBC: Primary biliary cholangitis; NITs: Noninvasive tests; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transpeptidase; VCTE: Vibration-controlled transient elastography; FIB4: Fibrosis-4 index.