Mogroside V protects against acetaminophen-induced liver injury by reducing reactive oxygen species and c-jun-N-terminal kinase activation in mice

Figure 1 Mogroside V attenuates acetaminophen-induced acute liver injury. A: Seven consecutive days of oral Mogroside V (MV) administration decreased serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in mice 24 hours after acetaminophen (APAP) treatment. n = 4-8 per group; B: A single dose of oral MV administration decreased serum ALT and AST levels in mice 6 and 24 hours following APAP treatment. n = 4-8 per group; C and D: A single dose of oral MV administration reduced the necrotic area and TUNEL⁺ cells in the livers of mice 12 hours after APAP exposure. n = 4 per group. Scale bar, 50 μm. ^aP < 0.05, ^bP < 0.01, ^cP < 0.001, ^dP < 0.0001. ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; MV: Mogroside V; APAP: Acetaminophen.