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©The Author(s) 2025.
World J Hepatol. Mar 27, 2025; 17(3): 103854
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103854
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103854
Table 2 Probiotics regulate the gut microbiota and related disease factors
Probiotics | Phylum (Gram negative/positive) | Changes | Function |
Bacillus subtilis + Enterococcus faecium[78] | Firmicutes (G+) | Firmicutes/Bacteroidetes↓ | IL-1β, IL-6, TNF-α↓ |
Akkermansia, Ruminococcus_UCG-014, Eubacterium_coprostanoligenes_group↑ | TLR4, NF-κB↓ | ||
Lachnoclostridium, Oscillibacter, Family_XIII_AD3011_group, Anaerovorax, Acetatifactor, Coriobacterium_UCG-002, Negativibacillus, Angelakisella, Ruminococcus, Harryflintia, Escherichia-Shigella↑ | LPS↓ | ||
Lactobacillus acidophilus KLDS1.0901[77] | Firmicutes (G+) | Roseburia, Lachnospiraceae UCG-006, Bacteroides, Enterorhabdus↓ | IL-1β, IL-6, TNF-α, LPS, Lactic acid↓ |
Blautia, Alistipes, Oscillibacter, Faecalibaculum, Ruminiclostridium, Lactobacillus, Ruminococcaceae UCG-009↑ | IL-10↑ | ||
Lactobacillus plantarum NCU116[76] | Firmicutes (G+) | Allobaculum, Lactobacillus, Bifidobacterium↑ | LPS↓ |
Intestinal barrier intact | |||
Bifidobacterium longum MG723, MG731[76] | Actinobacteria (G+) | F4/80, MCP-1, TGF-β, IL-1β, IL-18↓ | |
BAs↑ | |||
Bifidobacterium lactis, Bifidobacterium.longum DD98[76] | Actinobacteria (G+) | IL-6, IL-1β, TNF-α↓ | |
Bifidobacterium longum R0175[76] | Actinobacteria (G+) | Alloprevotella spp.↑ | IL-1, TNF-α, Chemokines↓ |
Acetatifactor muris, Butyricimonas spp., Oscillibacter spp.↓ | |||
Bifidobacterium longum LC67[76] | Actinobacteria (G+) | Firmicutes, Proteobacteria, Tyzzerella, Escherichia-Shigella, Nestiinimonas, Osillibacter, Ruminiclostridium↓ | |
Faecalibacterium, Lactobacillus↑ | |||
Bifidobacterium bifidum[76] | Actinobacteria (G+) | Tyzzerella, Escherichia-Shigella, Nestiinimonas, Osillibacter↓ | Propionate, butyrate↑ |
Faecalibacterium, Ruminococcus↑ | |||
Lactobacillus paracasei Jlus66[98] | Actinobacteria (G+) | Firmicutes↑ | IL-6, TNF-α, LPS↓ |
Proteobacteria, Clostridia↓ | IL-10↑ | ||
Clostridiaceae, Oscillospiraceae, Bifidobacteriaceae↑ | |||
Lactobacillus, Bifidobacterium↑ | |||
Lactiplantibacillus plantarum ZDY2013[75] | Actinobacteria (G+) | Lachnospirillaceae, Muribaculaceae, Lactobacillus spp., Alloprevotella and Blautia↑ | LPS/NF-κB↓ |
Fusobacteria, Verrucomicrobia↓ | Tight binding protein, IR↑ | ||
Lactobacillus sakei MJM60958[79] | Actinobacteria (G+) | Salmonella gallinarum KCTC 2931, E. coli O1 KCTC 2441, Salmonella cholerae KCTC 2932, Pseudomonas aeruginosa KCCM 11802↓ | Acetic acid↑ |
Akkermansia mucophila[23] | Verrucomicrobiota (G-) | γδT17, NF-κB, LPS↓ | |
Fat oxidation, Acetate, IL-10, Mucin (intestinal barrier integrity)↑ | |||
F. prausnitzii[84,86,87] | Firmicutes (G-) | Erysipelatoclostridium, Faecalibaculum, Blautia, Akkermansia, Bifidobacterium, Lactobacillus, Duboria↑ | TNF-α, IL-1β, IL-6, TLR4↓ |
Tyzzerella↓ | Butyrate, intestinal barrier↑ | ||
Christensenella minuta[88] | Firmicutes (G-) | Acetate, butyrate↑ | |
Bifidobacterium adolescentis[72] | Actinobacteria (G+) | Intestinal barrier↑ | |
TLR4/NF-κB, IL-6, IL-1β, TNF-α↓ | |||
Bacteroides ovatus[92] | Bacteroidetes (G-) | Lachnospiraceae_NK4A136_group, norank_f_Oscillospiraceae, Colidextribacterder↑ | SCFA, intestinal barrier↑ |
F/B, Ruminococcus_torques_group, Ruminococcus_gauvreauii_group, Erysipelothrix rhusiopathiae↓ | LPS, CD163, IL-1β, TNF-α↓ |
- Citation: Shu JZ, Huang YH, He XH, Liu FY, Liang QQ, Yong XT, Xie YF. Gut microbiota differences, metabolite changes, and disease intervention during metabolic - dysfunction - related fatty liver progression. World J Hepatol 2025; 17(3): 103854
- URL: https://www.wjgnet.com/1948-5182/full/v17/i3/103854.htm
- DOI: https://dx.doi.org/10.4254/wjh.v17.i3.103854