Effect of portal pressure gradient reduction on outcomes after transjugular intrahepatic portosystemic shunt in portal hypertension patients

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Mar 27, 2025 (publication date) through Apr 1, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Retrospective Cohort Study

World J Hepatol. Mar 27, 2025; 17(3): 103261
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103261

Table 5 Univariate and multivariate Cox regression analyses for liver failure before and after propensity score matching

Characteristics	Before PSM, univariate analyses (n = 815)			Before PSM, multivariate analyses (n = 815)			After PSM, univariate analyses (n = 662)			After PSM, univariate analyses (n = 662)
Characteristics	HR	95%CI	P	HR	95%CI	P	HR	95%CI	P	HR	95%CI	P
Group B	2.166	1.288-3.643	0.004^b	2.523	1.486-4.283	0.001^b	2.238	1.284-3.901	0.005^b	2.241	1.276-3.937	0.005^b
Creatinine	2.802	1.536-5.110	0.001^b	3.096	1.702-5.630	< 0.001^b	2.529	1.287-4.970	0.007^b	3.12	1.500-6.486	0.002^b
Right hepatic venous wedge pressure	2.614	1.223-5.586	0.013^a	2.643	1.229-5.680	0.013^a	1.941	0.858-4.392	0.112
Alanine aminotransferase	1.45	0.979-2.146	0.064				1.683	1.091-2.598	0.019^a	1.541	1.003-2.366	0.048^a
Cancer antigen 153	0.727	0.484-1.092	0.124				0.814	0.511-1.299	0.389
Platelet count	1.265	0.893-1.794	0.186				1.261	0.855-1.859	0.242
Carcinoembryonic antigen	0.877	0.639-1.202	0.414				0.852	0.597-1.218	0.38
C-Reactive protein							1.166	1.049-1.296	0.004^b	1.138	1.022-1.267	0.019^a
Alkaline phosphatase							1.461	0.909-2.348	0.117
Pre-TIPS right atrial pressure							1.595	0.882-2.884	0.123
International normalized ratio							0.283	0.044-1.845	0.187
Blood ammonia							0.704	0.440-1.129	0.145
Pre-TIPS MELD score							0.6	0.024-14.884	0.755
Activated partial thromboplastin time							2.952	0.880-9.905	0.08
Hemoglobin							2.551	0.903-7.205	0.077

^aP < 0.05.

^bP < 0.01.

HR: hazard ratio; PSM: Propensity score matching; TIPS: Transjugular intrahepatic portosystemic shunt; MELD: Model for end-stage liver disease.

Citation: Wang ZB, Zhu B, Meng MM, Wu YF, Zhang Y, Li DZ, Tian H, Wang FC, Lv YF, Ye QX, Liu FQ. Effect of portal pressure gradient reduction on outcomes after transjugular intrahepatic portosystemic shunt in portal hypertension patients. World J Hepatol 2025; 17(3): 103261
URL: https://www.wjgnet.com/1948-5182/full/v17/i3/103261.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i3.103261