Effect of portal pressure gradient reduction on outcomes after transjugular intrahepatic portosystemic shunt in portal hypertension patients

doi:10.4254/wjh.v17.i3.103261

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Mar 27, 2025; 17(3): 103261
Published online Mar 27, 2025. doi: 10.4254/wjh.v17.i3.103261

Table 4 Univariate and multivariate Cox regression analyses for hepatocellular carcinoma before and after propensity score matching

Characteristics	Before PSM, univariate analyses (n = 815)			Before PSM, multivariate analyses (n = 815)			After PSM, univariate analyses (n = 662)			After PSM, univariate analyses (n = 662)
Characteristics	HR	95%CI	P	HR	95%CI	P	HR	95%CI	P	HR	95%CI	P
Group B	0.332	0.154-0.713	0.005^b	0.37	0.171-0.800	0.012^a	0.346	0.149-0.802	0.013^a	0.374	0.160-0.874	0.023^a
Creatinine	3.098	1.406-6.828	0.005^b	2.144	0.868-5.297	0.098	3.091	1.434-6.662	0.004^b	3.253	1.442-7.340	0.004^b
Prothrombin time activity	0.593	0.293-1.201	0.147				0.178	0.039-0.813	0.026^a	0.128	0.026-0.623	0.011^a
Pre-TIPS MELD score	58.775	1.249-2766.772	0.038^a	13.367	0.160-1115.608	0.251
Female	0.422	0.163-1.093	0.075
Alanine aminotransferase	0.63	0.377-1.053	0.078
Pre-TIPS inferior vena cava pressure	0.579	0.281-1.193	0.139
White blood cell count	0.635	0.337-1.194	0.159
Chlorine	26.688	0.261-2726.917	0.164
Blood ammonia	0.737	0.390-1.393	0.348
C-reactive protein	1.058	0.931-1.203	0.387
Hemoglobin	1.59	0.402-6.288	0.508

^aP < 0.05.

^bP < 0.01.

HR: hazard ratio; PSM: Propensity score matching; TIPS: Transjugular intrahepatic portosystemic shunt; MELD: Model for end-stage liver disease.

Citation: Wang ZB, Zhu B, Meng MM, Wu YF, Zhang Y, Li DZ, Tian H, Wang FC, Lv YF, Ye QX, Liu FQ. Effect of portal pressure gradient reduction on outcomes after transjugular intrahepatic portosystemic shunt in portal hypertension patients. World J Hepatol 2025; 17(3): 103261
URL: https://www.wjgnet.com/1948-5182/full/v17/i3/103261.htm
DOI: https://dx.doi.org/10.4254/wjh.v17.i3.103261