Yinchenhao decoction alleviates obstructive jaundice liver injury by modulating epidermal growth factor receptor and constitutive androstane receptor signaling

Figure 7 The schematic representation of the potential mechanisms underlying the therapeutic effects of Yinchenhao decoction in the treatment of obstructive jaundice. Yinchenhao decoction (YCHD) enhances bile acid metabolism and active transport within liver cells and increases bile acid excretion by proximal renal tubular epithelial cells. The therapeutic effects of YCHD are likely due to its inhibition of epidermal growth factor receptor activation, which promotes constitutive androstane receptor (CAR) expression and facilitates CAR nuclear heterotopia. YCHD: Yinchenhao decoction; EGFR: Epidermal growth factor receptor.