Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling

Figure 5 Hepatitis B virus-miR-3 antagomir inhibited hepatitis B virus replication. A-C: HepG2 cells transfected with pHBV1.3 were treated with an HBV-miR-3 inhibitor for 72 hours, resulting in alterations in hepatitis B virus (HBV) DNA (A), HBV pgRNA (B), and HBsAg (C); D-F: HepG2-NTCP cells were infected with HBV from HepG2.2.15 cell supernatant and treated with an HBV-miR-3 antagomir for 72 hours, resulting in alterations in HBV DNA (D), HBV pgRNA levels (E), and HBsAg (F). Each experiment was repeated three times. The data are presented as mean ± SD. NC: Negative control; HBV: Hepatitis B virus.