Hepatitis B virus confers innate immunity evasion through hepatitis B virus-miR-3 down-regulation of cGAS-Sting-IFN signaling

Figure 4 Hepatitis B virus-miR-3 antagomir resued cGAS-Sting pathway activity. A: Effect of 72-hour HBV-miR-3 antagomir treatment on the cGAS-Sting pathway in HepG2 cells transfected with various dosages of pHBV1.3; B: Expression of the cGAS-Sting pathway in HepG2.2.15 cells after a 72-hour treatment with HBV-miR-3 antagomir; C: Expression of the cGAS-Sting pathway in HepG2-NTCP cells infected with hepatitis B virus from HepG2.2.15 supernatant after 72 hours of HBV-miR-3 inhibitor treatment. Each experiment was conducted three times. Data are presented as mean ± SD.