Uncovering immune cell heterogeneity in hepatocellular carcinoma by combining single-cell RNA sequencing with T-cell receptor sequencing

Figure 4 Cell communication analysis of CD8⁺ T and CD4⁺ T-cell subsets. A: Bubble map showing signaling pathways upregulated among cell subpopulations in tumors. The abscissa is the ligand-acceptor pair; the ordinate is the cell type alignment group. The tissue type is noted in the parentheses; B and C: Strength mapping of outgoing signaling pathways in different tissues for each cell subpopulation in P0301. DC: Dendritic cell; NK: Natural killer; Treg: Regulatory T cells.