Clinical characteristics of patients with hepatitis and cirrhosis and the construction of a prediction model

Table 4 Comparison of clinical data between the validation cohort hepatitis group and the hepatitis cirrhosis group, mean ± SD/n (%)

Index		Total cases (n = 321)	Hepatitis group (n = 295)	Hepatitis cirrhosis group (n = 26)	t/χ2/Z	P value
Gender	Man	192 (59.81)	180 (61.02)	12 (46.15)	2.196	0.138
	Woman	129 (40.19)	115 (38.98)	14 (53.85)
Age (years)			46.89 ± 21.68	53.85 ± 9.03	1.623	0.106
Hepatitis classification	Mild	81 (25.23)	78 (26.44)	3 (11.54)	1.718	0.086
	Moderate	215 (66.98)	195 (66.10)	20 (76.92)
	Serious	25 (7.79)	22 (7.46)	3 (11.54)
Alb (× 109/L)		43.32 ± 4.79	43.44 ± 3.70	41.97 ± 2.64	1.981	0.049
LDH (U/L)		212.28 ± 129.41	203.94 ± 66.37	306.92 ± 390.42	3.979	0.000
CHE (U/L)		7557.79 ± 2369.69	7617.54 ± 1352.37	6879.85 ± 1506.37	2.642	0.009
PTA (%)		112.61 ± 17.40	114.05 ± 16.15	96.36 ± 22.54	5.166	0.000
HBeAg (S/CO)		323.60 ± 526.52	340.11 ± 333.91	136.59 ± 395.57	2.933	0.004
WBC (× 109/L)		5.20 ± 1.59	5.28 ± 1.57	4.30 ± 1.48	3.065	0.002
RBC (× 1012/L)		4.74 ± 0.49	4.76 ± 0.48	4.46 ± 0.47	3.060	0.002
HGB (g/L)		145.22 ± 16.54	145.96 ± 15.98	136.77 ± 20.42	2.744	0.006
ANC (× 109/L)		2.89 ± 1.25	2.94 ± 1.26	2.24 ± 0.96	2.761	0.006
ALC (× 109/L)		1.84 ± 0.64	1.85 ± 0.45	1.63 ± 0.41	2.406	0.017
GOT/GPT		0.78 ± 0.46	0.77 ± 0.46	1.00 ± 0.44	2.452	0.015
INR		1.00 ± 0.11	0.99 ± 0.22	1.11 ± 0.12	2.743	0.006
PT (second)		11.57 ± 1.38	11.45 ± 0.96	12.95 ± 3.35	5.576	0.000
HA (ng/mL)		125.87 ± 134.61	124.44 ± 34.51	142.08 ± 37.40	2.482	0.014
LN (μg/L)		49.87 ± 33.43	48.29 ± 31.21	67.75 ± 49.89	2.878	0.004
PLT (× 109/L)		181.54 ± 63.11	185.44 ± 61.16	137.27 ± 69.18	3.809	0.000

Alb: Albumin; LDH: Lactate dehydrogenase; CHE: Cholinesterase; WBC: White blood cell; RBC: Red blood cell; HGB: Hemoglobin; ANC: Absolute neutrophil count; ALC: Absolute lymphocyte count; PTA: Prothrombin activity; GOT: Aspartate aminotransferase; GPT: Alanine aminotransferase; HBeAg: Hepatitis B E antigen; INR: International normalized ratio; PT: Plasma prothrombin time; HA: Hyaluronic acid; LN: Laminin; PLT: Platelet count.