Clinical characteristics of patients with hepatitis and cirrhosis and the construction of a prediction model

Table 2 Comparison of clinical data between the hepatitis group and the hepatitis cirrhosis group in the modeling cohort, mean ± SD/n (%)

Index		Total cases (n = 749)	Hepatitis group (n = 688)	Hepatitis cirrhosis group (n = 61)	t/χ2/Z	P value
Gender	Man	487 (65.02)	447 (64.97)	40 (65.57)	0.009	0.924
	Woman	262 (34.98)	241 (35.03)	21 (34.43)
Age (years)			46.12 ± 22.80	51.79 ± 10.06	1.925	0.051
Hepatitis classification	Mild	161 (21.50)	152 (22.09)	9 (14.75)	1.342	0.180
	Moderate	538 (71.83)	491 (71.37)	47 (77.05)
	Serious	50 (6.68)	45 (6.54)	5 (8.20)
Allergy history		44 (5.87)	40 (5.81)	4 (6.56)	0.002	0.963
Disease history	Hypertension	41 (5.47)	38 (5.52)	3 (4.92)	0.605	0.545
	Diabetes	38 (5.07)	35 (5.09)	3 (4.92)
	Heart disease	30 (4.01)	29 (4.22)	1 (1.64)
Operation history		99 (13.22)	90 (13.08)	9 (14.75)	0.137	0.712
Smoking history		95 (12.68)	86 (12.50)	9 (14.75)	0.257	0.612
Drinking history		90 (12.02)	82 (11.92)	8 (13.11)	0.769	0.380
Family history of disease		572 (76.37)	520 (75.58)	52 (85.25)	2.900	0.089
Treatment regimen	Monotherapy	623 (83.18)	568 (82.56)	55 (90.16)	2.317	0.128
	Combination therapy	126 (16.82)	120 (17.44)	6 (9.84)
Alb (× 109/L)		43.02 ± 4.65	43.10 ± 4.60	42.13 ± 1.06	2.891	0.004
LDH (U/L)		210.07 ± 73.36	210.33 ± 11.13	207.17 ± 10.49	2.133	0.033
CHE (U/L)		7298.93 ± 2190.67	7336.36 ± 1184.27	6876.75 ± 1236.59	2.895	0.004
PTA (%)		108.16 ± 19.22	108.92 ± 19.13	99.62 ± 18.22	3.653	0.000
HBeAg (S/CO)		2355.23 ± 38449.88	2543.73 ± 314.87	229.18 ± 303.99	55.175	0.000
WBC (× 109/L)		5.19 ± 1.51	5.25 ± 1.51	4.55 ± 1.22	3.520	0.001
RBC (× 1012/L)		4.73 ± 0.51	4.74 ± 0.31	4.64 ± 0.23	2.460	0.014
HGB (g/L)		145.56 ± 15.96	145.70 ± 6.12	143.97 ± 3.97	2.167	0.031
ANC (× 109/L)		2.81 ± 1.07	2.85 ± 1.09	2.45 ± 0.81	2.798	0.005
ALC (× 109/L)		1.88 ± 0.66	1.90 ± 0.66	1.69 ± 0.60	2.399	0.017
GOT/GPT		0.75 ± 0.42	0.74 ± 0.42	0.86 ± 0.36	2.162	0.031
INR		1.03 ± 0.11	1.02 ± 0.12	1.07 ± 0.13	3.097	0.002
PT (second)		11.84 ± 1.38	11.79 ± 1.37	12.35 ± 1.43	3.049	0.002
HA (ng/mL)		147.90 ± 145.41	144.64 ± 142.14	184.75 ± 175.34	2.069	0.039
LN (μg/L)		56.44 ± 45.54	55.72 ± 24.77	64.63 ± 23.16	2.706	0.007
PLT (× 109/L)		439.84 ± 5251.83	179.83 ± 54.36	3372.49 ± 18283.84	4.612	0.000

Alb: Albumin; LDH: Lactate dehydrogenase; CHE: Cholinesterase; WBC: White blood cell; RBC: Red blood cell; HGB: Hemoglobin; ANC: Absolute neutrophil count; ALC: Absolute lymphocyte count; PTA: Prothrombin activity; GOT: Aspartate aminotransferase; GPT: Alanine aminotransferase; HBeAg: Hepatitis B E antigen; INR: International normalized ratio; PT: Plasma prothrombin time; HA: Hyaluronic acid; LN: Laminin; PLT: Platelet count.