Global landscape of hepatic organoid research: A bibliometric and visual study

Table 4 Top 10 cocited references and main findings in hepatic organoid research

Rank	Ref.	Count	Main findings
1	Huch M et al[25], 2015, Cell, volume 160	100	Established a long-term and stable human liver organoid culture condition, in which liver organoid can differentiate to functional hepatocytes and model liver disease
2	Hu HL et al[26], 2018, Cell, volume 175	82	Establishment of a long-term 3D organoid culture system for mouse and human primary hepatocytes from single hepatocytes, while retaining key morphological, functional and gene expression features
3	Broutier L et al[27], 2017, Nature Medicine, volume 23	79	Extend the culture system to the propagation of primary liver cancer organoids from three of the most common primary liver cancer subtypes
4	Broutier L et al[23], 2016, Nature Protocols, volume 11	78	Developed culture conditions for self-renewing 3D organoids that allow the long-term expansion of adult primary tissues from human and mouse adult liver and pancreas
5	Ouchi R et al[28], 2019, Cell Metabolism, volume 30	55	Developed a reproducible method to derive multi-cellular human liver organoids composed of hepatocyte-, stellate-, and Kupffer-like cells that exhibit transcriptomic resemblance to in vivo-derived tissues
6	Clevers H[4], 2016, Cell, volume 165	47	Reviewed the organoid applications in modeling human organ development and pathologies as well as personalized medicine
7	Huch M et al[29], 2013, Nature, volume 494	44	Lgr5+ stem cells in actively self-renewing tissues can also be extended to damage-induced stem cells in a tissue with a low rate of spontaneous
8	Van de Wetering M et al[30], 2015, Cell, volume 161	42	Established the tumor organoid cultures from 20 consecutive colorectal carcinoma patients
9	Takebe T et al[31], 2013, Nature, volume 499	42	This is the first report demonstrating the generation of a functional human liver organ from pluripotent stem cells
10	Boj SF et al[32], 2015, Cell, volume 160	39	Generated the pancreatic cancer-derived organoids and revealed that they are suitable for ductal pancreatic cancer research

3D: Three-dimensional.