Role of triggering receptor expressed on myeloid cells 2 in the pathogenesis of non-alcoholic fatty liver disease

Figure 6 Interaction of triggering receptor expressed on myeloid cells 2 with other molecular pathways in non-alcoholic fatty liver disease. Triggering receptor expressed on myeloid cells 2 (TREM2) high-expressing macrophages have phagocytosic and anti-fibrotic functions, and improve lipid/lipoprotein processing. TREM2 Low-expressing macrophages are enriched in metapathways associated with inflammation, enhanced cytokine signaling, and cell death. AKT: Protein kinase B; ERK: Extracellular regulating kinase; IL: Interleukin; NF-κB: Nuclear factor-kappa B; NOD: Nucleotide-binding oligomerization domain; PI3K: Phosphatidylinositol 3-kinase; ROS: Reactive oxygen species; TGF: Transforming growth factor; TLR: Toll like receptor; TNF: Tumor necrosis factor.