Clinical features and prognosis of drug-induced liver injury in patients with non-alcoholic fatty liver

Table 4 Comparison of biochemical indices in the two groups

	DILI (n = 89)	DILI + NAFL (n = 110)	P value
ALT (U/L)	765.7 (360.25, 1016.35)	523.35 (169.5, 1078.5)	0.069
AST (U/L)	471.4 (259.9, 658.2)	438.5 (127.5, 920.2)	0.715
γ-GT (U/L)	169 (101.3, 246.1)	202 (97.5, 391.73)	0.071
ALP (U/L)	155.8 (111, 189.85)	129.3 (93, 168.15)	0.509
LDH (IU/L)	259 (220.5, 309)	228 (179, 306)	0.511
TBA (μmol/L)	33 (7, 136)	36.75 (4.85, 142.03)	0.243
TBiL (μmol/L)	59.5 (21.95, 136.3)	74.1 (19.4, 202.63)	0.265
DBIL (μmol/L)	19.6 (6.6, 88.6)	43.4 (4.7, 122.35)	0.965
IBIL (μmol/L)	20.4 (11.65, 29.9)	17.7 (10.43, 35.15)	0.651
TP (g/L)	68.55 ± 7.78	69.45 ± 6.86	0.342
ALB (g/L)	40.29 ± 4.46	40.00 ± 5.07	0.674
TG (mmol/L)	1.57 (1, 2.195)	1.805 (1.435, 2.55)	0.006
CHO (mmol/L)	4.15 (3.51, 4.96)	4.58 (3.9, 5.43)	0.003
LDL (mmol/L)	2.29 (1.87, 2.82)	2.78 (2.03, 3.4)	0.008
HDL (mmol/L)	1.1 (0.87,1.46)	1.14 (0.8,1.39)	0.292
GLU (mmol/L)	5.34 (4.95, 5.79)	5.59 (4.94, 6.38)	0.113
HbA1C (%)	5.7 (5.3, 7.9)	6.5 (5.83, 7.08)	0.291
Insulin (μIU/mL)	9.62 (6.18, 13.14)	12.87 (9.96, 19.4)	0.022

DILI: Drug-induced liver injury; NAFL: Nonalcoholic fatty liver; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase. γ-GT: γ-glutamyl transpeptidase; ALP: Alkaline phosphatase; LDH: Lactate dehydrogenase; TBA: Total bile acids; TBiL: Total bilirubin; DBiL: Direct bilirubin; IBiL: Indirect bilirubin; TP: Total protein; ALB: Albumin; TG: Triglycerides; CHO: Cholesterol; LDL: Low-density lipoprotein; HDL: High-density lipoprotein; GLU: Glucose; HbA1C: Hemoglobin A1C.