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©The Author(s) 2025.
World J Hepatol. Feb 27, 2025; 17(2): 101741
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.101741
Published online Feb 27, 2025. doi: 10.4254/wjh.v17.i2.101741
Table 3 Possible hepatotoxic drugs in the study cohort
Medication history | DILI | DILI + NAFL |
Chinese medicine, proprietary Chinese medicine | Lianhua Qingdian (Mianma Guanzhong) | Gynostemma Total Glycosides Tablets |
Warm Stomach Shule (Astragalus, Yanhusuo) | Gastrointestinal An | |
Danlu Tongdu Tablet (Salvia miltiorrhiza, Astragalus membranaceus, Yanhuosuo) | Kun Bao Wan (Prepared He Shou Wu, Astragalus) | |
Xian Ling Bone Fructus Capsule (Radix et Rhizoma Polygoni Multiflori, Salviae Miltiorrhizae) | Uterine Blood Ning | |
Milk fetish elimination (Poria cocos) | Shen Xiang Shu Yu (Yan Hu Suo, Chai Hu) | |
Lingbao Heart Protecting Tablets (Salvia miltiorrhiza) | Gentiana Macrophyllae Capsules | |
Nourishing Heart Tablets (Astragalus, Yanhusuo, Salvia Miltiorrhiza) | Panax ginseng powder | |
Golden Chamber Kidney Qi Pills (Zelda) | Bailemian (Containing Shouwu Teng) | |
Rejuvenation (Zedoary, Shouwu Teng) | Dan Hong (Salvia miltiorrhiza) | |
Bailomian (Shouwu Teng) | Moistening Dryness and Relieving Itching Capsule (He Shouwu, Prepared He Shouwu) | |
Zidan Blood Capsules (Panax ginseng saponin, Radix et Rhizoma Ginseng) | Salvia divinorum Drops (Salvia divinorum) | |
Bai Cao Yishou Tea (Astragalus) | Exquisite Yin Qiao Tablets | |
Ganoderma Lucidum Spore Powder | Tongxin Nourishing Heart (Prepared He Shouwu) | |
Brain Heart (Astragalus, Salvia Miltiorrhiza, Scorpion, Leech) | Di Ao Heart Blood Kang | |
Jia Wei Yi Puan (Mentha piperita, Chai Hu) | Mudan Granules (Huang's, Yanhuisuo, Panax ginseng, Paeonia lactiflora, Paeonia lactiflora, Salvia miltiorrhiza, Chuan Gong, Safflower, Sumac, Chickweed) | |
Antelope Clear Lung Capsule (Smallpox Powder, Mint) | Xintong Oral Liquid (Astragalus, He Shouwu, Salvia Miltiorrhiza) | |
Jumbo Pills (Clove) | Lipitor (Zedoary) | |
Osteoporosis (Astragalus, Danshen) | Niu Huang Blood Pressure Reducing Pill (Astragalus, Mentha piperita) | |
Deer Chuan Activating Capsule (Scorpion, Yanhuisuo) | Dendrobium Nightshade Pill | |
Stomach-clearing Huanglian Pill (Smallpox Powder, Astragalus) | Gynostemma Capsules (Radix et Rhizoma Ginseng, Radix et Rhizoma Serpentae, Radix et Rhizoma Pinelliae, Radix et Rhizoma Bitterwood, Pericarpium Laminariae, Icicle, Menthol) | |
Pu Shen Capsule (He Shou Wu, Pu Huang) | Sanwu Capsule (Shouwu Teng) | |
Huo Xiang Zheng Qi Capsule (Semen Armeniacae) | Lianhua Qingdian (Mianma Guanzhong) | |
Nourishing Blood and Nourishing Kidney Pill (Prepared He Shouwu) | Wind-dispersing and pain-relieving granules (Chai Hu) | |
Nourishing the Heart by Nourishing the Veins (Prepared He Shouwu) | Blue Scutellaria Oral Liquid (Astragalus) | |
Compound Danshen Drop Pills (Salvia divinorum) | Shu Shen Ling (Shou Wu Teng) | |
Tangerine Red Phlegm and Cough Liquid (Semen Huperzia) | Nourishing Blood and Clearing Brain (Yanhuosuo) | |
Gui Zhi Fu Ling Capsules | Compound Rheumatism Ning | |
Betel Nut Si-Xie Tablet | Inibi Tablets | |
Shuanghuanglian (Astragalus) | Inibalance Pills (Roasted Astragalus, Chai Hu) | |
Hematoxylin (Chai Hu) | Qingdianxie Tablet (Smallpox Powder, Astragalus, Chai Hu) | |
Pu Shen Capsule (He Shou Wu, Ze Xie) | Dong Ling Cao Tablet | |
Ginkgo Biloba Ketone Ester Dispersible Tablets | Tongxuanliang Pill (Semixia, Astragalus) | |
Muxiang Shunqi | Tiger Balm Tablets | |
Liu Wei Di Huang Pill | Gui Long Tendon & Bone Ning (Salvia miltiorrhiza) | |
Yanshou Tablets | Golden Throat Pills (Acacia Pi) | |
Heze | Zachong Thirteen Flavor Pills (Clove) | |
Shouwu Teng | Shu Brain Xin Drops | |
Lei Gong Teng | Xihuang Pills | |
Saffron | Zijin Long Tablets (Astragalus and Salvia Miltiorrhiza) | |
Zedoary | Bornin (Roasted Astragalus) | |
He Shou Wu | Zhen's Fu Zheng (Astragalus) | |
Pingxiao Capsules | ||
Yin Qiao Tablet | ||
Pientzehuang Tablet | ||
Formula: (1) Fried Sophora japonica, Fried Bitter Almond, Pueraria Mirifica, Paeoniae Alba, Cortex Pseudostellariae, Peony Peel, Roasted Licorice, Ascorbic Acid, Gypsum, Ephedra, Cinnamon Branches, Cicada Shell | ||
(2) Forsythia, Rhizoma Atractylodis Macrocephalae, Roasted Epimedium, Cinnamon Branches, Folium Artemisiae, Hei Shun Piece, Jujubes, Ginger, Sequelae, Wine Huang Cen, Zingiber officinale, Burnt Hawthorn, Taraxacum officinale | ||
(3) Lycium barbarum, licorice, Radix Fructus Fructus, Fructus Chrysanthemi, Semen Coicis, Mulberry Leaf, Gardenia Jasminoides, Oyster, Cassia Seed, Lotus Seed | ||
(4) Gypsum, Zhi Mu, Radix et Rhizoma Ginseng, Pollen, Poria cocos, Morus alba, Zhe Bei, Xuan Shen, Ophiopogon, Chrysanthemum, Radix et Rhizoma Sheng Di | ||
Salvia miltiorrhiza | ||
Radix Bupleurum Chinense | ||
He Shou Wu | ||
Psoralea rubra | ||
Senna | ||
Xiaku Cao Cao Cream | ||
Deer Whip Cream | ||
Ginseng | ||
Lei Gong Teng | ||
Scorpion | ||
Leech | ||
Zezhi diarrhea (used in TCM) | ||
Acanthopanax Senticosus | ||
Dragon's blood exhaust | ||
Dandelion | ||
Western medicine | ||
Anti-infective drugs | Cefoperazone sodium sulbactam sodium, furotoxin, levofloxacin, azithromycin, amoxicillin, clindamycin, isoniazid, rifampicin, streptomycin, bispyrazinamide | Levofloxacin, furotoxin, amoxicillin, itraconazole, roxithromycin |
Nonsteroidal anti-inflammatory drug | Loxoprofen, Lovenox Extended-Release Tablets, Acetaminophen | Saxifrage, aminopyrine, aminocaprofen tablets, cotrimoxazole, nimesulide |
Cardiovascular drugs | Fluvastatin, Rosuvastatin, Propafenone | Amlodipine benzenesulfonate, aliskatam, nifedipine, irbesartan hydrochlorothiazide, valsartan, felodipine, trandolazine, atorvastatin, simvastatin, acyclovir, atorvastatin, simvastatin, acyclovir, propafenone |
Antitumor drugs | ||
Antiulcer drug | Omeprazole (antifungal agent) | Lansoprazole, Rabeprazole |
Psychotropic drugs | Flunarizine hydrochloride, betahistine mesylate, clonazepam, trazodone | |
Hormone antagonists | Letrozole, exemestane, tamoxifen citrate | |
Other | Mothballs (naphthalene or p-dichlorobenzene), toluene | Glucosamine, analgesic injections (ketorolac tromethamine, resorcinol), eteplirisone hydrochloride tablets, methimazole |
Dietary supplement | Amway Health Care, Herbalife, Jens United States | Bovine Vitamin Tablets, Enzymes, Glutamine |
- Citation: Zhao Y, Li JZ, Liu YG, Zhu YJ, Zhang Y, Zheng WW, Ma L, Li J, Wang CY. Clinical features and prognosis of drug-induced liver injury in patients with non-alcoholic fatty liver. World J Hepatol 2025; 17(2): 101741
- URL: https://www.wjgnet.com/1948-5182/full/v17/i2/101741.htm
- DOI: https://dx.doi.org/10.4254/wjh.v17.i2.101741