Modern ultrasound techniques for diagnosing liver steatosis and fibrosis: A systematic review with a focus on biopsy comparison

Table 8 Vibration-controlled transient elastography diagnostic efficacy (area under the receiver operating characteristic curves for fibrosis detection)

Ref.	Number of patients	Disease/diagnose	Diagnostic method	Fibrosis stage	AUROC (CI)	Assessment
Cassinotto et al[23]	577	NAFLD	VCTE	F ≥ 2	0.80 (0.76-0.84)	Acceptable
				F ≥ 3	0.82 (0.78-0.86)	Good
				F4	0.85 (0.80-0.90)	Good
Gatos et al[27]	152	CLD	VCTE	F ≥ F1	0.9900	Excellent
				F ≥ F2	0.9767	Excellent
				F ≥ F3	0.9651	Excellent
				F = F4	0.9645	Excellent
Imajo et al[66]	231	NAFLD	VCTE	F4	0.87 (0.80-0.91)	Good
Nogami et al[36]	163	NAFLD	VCTE	≥ F2	0.855 (0.83-0.94)	Good
				≥ F3	0.925 (0.90-0.95)	Excellent
				F4	0.88 (0.87-0.89)	Good
Sharpton et al[43]	114	CLD	VCTE	F2-F4	0.86 (0.80-0.93)	Good
				F3-F4	0.91 (0.82-0.99)	Excellent
				F4	0.96 (0.91-1.00)	Excellent
Atzori et al[22]	160	CLD	VCTE	F0/1	0.810 (0.746-0.884)	Good
				F3/4	0.841 (0.771-0.910)	Good
				F4	0.939 (0.896-0.982)	Excellent
Damjanovska et al[24]	93	NAFLD	VCTE	F4	0.77 (0.66-0.88)	Acceptable
Mikolasevic et al[35]	179	NAFLD	VCTE	≥ F3	0.98	Excellent
				F4	0.98	Excellent
Roccarina et al[40]	671	NAFLD	VCTE	F > 1	0.792 (0.60-0.91)	Acceptable
				F > 2	0.849 (0.78-0.91)	Good
				F > 3	0.851 (0.79-0.91)	Good
				F = 4	0.911 (0.83-0.96)	Excellent
Zougmoréet al[55]	476	CLD	VCTE	≥ F2	0.86 (0.81-0.91)	Good
				≥ F3	0.89 (0.85-0.93)	Good
				≥ F4	0.90 (0.86-0.94)	Good

AUROC: Area under the receiver operating characteristic curve; NAFLD: Nonalcoholic fatty liver disease; CLD: Chronic liver disease; VCTE: Vibration-controlled transient elastography.