Modern ultrasound techniques for diagnosing liver steatosis and fibrosis: A systematic review with a focus on biopsy comparison

Table 5 Shear wave elastography diagnostic efficacy (area under the receiver operating characteristic curves for fibrosis detection)

Ref.	Number of patients	Disease/diagnose	Diagnostic method	Fibrosis stage	AUROC (CI)	Assessment
Gatos et al[27]	152	CLD	SWE	F ≥ F1	0.9621	Excellent
				F ≥ F2	0.9931	Excellent
				F ≥ F3	0.9835	Excellent
				F = F4	0.9656	Excellent
				F0	0.995 (0.988-1.00)	Excellent
				F1	0.676 (0.589-0.763)	Unacceptable
				F2	0.507 (0.409-0.605)	Unacceptable
				F3	0.708 (0.621-0.795)	Good
				F4	0.932 (0.889-0.975)	Excellent
Laroia et al[30]	124	CLD	SWE	Combined F1 + F2	0.612 (0.516-0.708)	Unacceptable
				Combined F3 + F4	0.961 (0.933-0.990)	Excellent
Ogino e t al[37]	107	NAFLD	SWE	F2	0.88	Good
				F3	0.87	Good
				F4	0.92	Excellent
Zhang et al[70]	100	NAFLD	SWE	≥ 1	0.65 (0.54-0.76)	Unacceptable
				≥ 2	0.81 (0.71-0.91)	Good
				≥ 3	0.85 (0.74-0.96)	Good
				4	0.91 (0.79-1.00)	Excellent
Wang et al[49]	210	HCC	SWE	≥ F2	0.895 (0.842-0.947)	Good
				≥ F3	0.877 (0.826-0.927)	Good
				= F4	0.854 (0.803-0.905)	Good
Zougmoré et al[55]	476	CLD	SWE	≥ F2	0.91 (0.88-0.96)	Excellent
				≥ F3	0.93 (0.89-0.97)	Excellent
				≥ F4	0.96 (0.94-0.98)	Excellent
Kim et al[67]	60	NASH	SWE	≥ F1	0.777 (0.653-0.777)	Acceptable
				≥ F2	0.747 (0.611-0.854)	Acceptable
				≥ F3	0.861 (0.742-0.940)	Good
				≥ F4	0.846 (0.730-0.926)	Good
Yang et al[50]	106	CLD	SWE	F0 vs F1-3	0.91	Excellent
				F0-1 vs F2-4	0.84	Good
				F0-2 vs F3-4	0.79	Acceptable
				F0-3 vs F4	0.76	Acceptable

AUROC: Area under the receiver operating characteristic curve; CLD: Chronic liver disease; SWE: Shear wave elastography; NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis; HCC: Hepatocellular carcinoma.