Review
Copyright ©The Author(s) 2025.
World J Hepatol. Jan 27, 2025; 17(1): 102273
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.102273
Table 1 Biomarkers for liver disease identified through protein and sequencing analysis
Applied method
Biomarkers (Target proteins and genes)
Ref.
Detection of protein contentAFP, DCP, GPC3, GGT, IL-8Zhao et al[20]; Hu et al[21]; Hanif et al[22]; Lai et al[23]; Bertino et al[24]; Zhou et al[25]; Shimizu et al[26]
Epigenetic modificationCDH1, RASSF1A, GSTP, SOCS1, SFRP1, PTEN, p16, p21, p27 and m6A methylation of HBV RNARaggi and Invernizzi[65]; Kostyusheva et al[66]
Targeted NGSTP53, TERT and TSC2Lin et al[113]
WGSCDKN2A, CCND1, APC, TERT, ASH1L, NCOR1, and MACROD2, ARID1A, TTC28, LRP1B and BCL9Fujimoto et al[118]; Zhou et al[119]
WESPCK2, HUWE1, ARID1A, RPS6KA3, NFE2L2, IRF2, APOB, P53, Keap1, CDKN1A, XPO1 and HIST1H1EGnirke et al[114]; Liu et al[115]; Guichard et al[116]; Zhou et al[117]
RNA-seqPTPRC and FOXP3Zhang et al[121]