Copyright
©The Author(s) 2025.
World J Hepatol. Jan 27, 2025; 17(1): 102273
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.102273
Published online Jan 27, 2025. doi: 10.4254/wjh.v17.i1.102273
Applied method | Biomarkers (Target proteins and genes) | Ref. |
Detection of protein content | AFP, DCP, GPC3, GGT, IL-8 | Zhao et al[20]; Hu et al[21]; Hanif et al[22]; Lai et al[23]; Bertino et al[24]; Zhou et al[25]; Shimizu et al[26] |
Epigenetic modification | CDH1, RASSF1A, GSTP, SOCS1, SFRP1, PTEN, p16, p21, p27 and m6A methylation of HBV RNA | Raggi and Invernizzi[65]; Kostyusheva et al[66] |
Targeted NGS | TP53, TERT and TSC2 | Lin et al[113] |
WGS | CDKN2A, CCND1, APC, TERT, ASH1L, NCOR1, and MACROD2, ARID1A, TTC28, LRP1B and BCL9 | Fujimoto et al[118]; Zhou et al[119] |
WES | PCK2, HUWE1, ARID1A, RPS6KA3, NFE2L2, IRF2, APOB, P53, Keap1, CDKN1A, XPO1 and HIST1H1E | Gnirke et al[114]; Liu et al[115]; Guichard et al[116]; Zhou et al[117] |
RNA-seq | PTPRC and FOXP3 | Zhang et al[121] |
- Citation: Shi J, Zhu X, Yang JB. Advances and challenges in molecular understanding, early detection, and targeted treatment of liver cancer. World J Hepatol 2025; 17(1): 102273
- URL: https://www.wjgnet.com/1948-5182/full/v17/i1/102273.htm
- DOI: https://dx.doi.org/10.4254/wjh.v17.i1.102273