Predictors of survival in autoimmune liver disease overlap syndromes

Table 1 Patient characteristics at baseline and comparison of baseline characteristics between autoimmune hepatitis and primary biliary cholangitis overlap and autoimmune hepatitis and primary sclerosing cholangitis overlap subgroups, n (%)

Characteristics	AILDOS (n = 22) (all patients)	AIH-PBC (n = 14)	AIH-PSC (n = 8)	P value
Age, median (range) years	46.7 (17.8-82.1)	55.8 (26.9-82.1)	23.3 (17.8-62.0)	0.008b
Male	8 (36.4)	5 (35.7)	3 (37.5)	0.935
Hepascore, median (range)	1 (0.07-1)	1 (0.07-1)	0.91 (0.12-1)	0.628
LOS, median (range)	5.75 (1.46-13.7)	5.98 (2.41-13.65)	4.18 (1.46-6.49)	0.143
MELD, median (range)	8 (6-12)	8.5 (6-12)	6 (6-11)	0.427
MELD-Na, median (range)	10 (6-14)	9.5 (6-14)	10 (6-13)	0.966
Mayo Score, median (range)	0.76 (-1.28-2.92)	0.79 (-0.50-2.92)	0.1 (-1.28-1.9)	0.256
Variceal bleeding history	2 (9.1)	1 (7.1)	1 (12.5)	1.000
WCC, median (range)	5.20 (2.43-7.94)	5.4 (4.4-7.94)	3.2 (2.43-6.8)	0.052
Hb low	5 (25)	2 (15.4)	3 (42.9)	0.290
Platelet, median (range)	(35-514)	173 (69-514)	153 (35-388)	0.843
INR, median (range)	1 (0.9-1.3)	1.05 (0.9-1.2)	1 (0.9-1.3)	0.794
Bilirubin, median (range)	17 (3-62)	17.8 (7-62)	13 (3-56)	0.561
ALT, median (range)	67.5 (14-677)	72 (14-677)	55 (24-137)	0.250
ALP, median (range)	146 (20-1200)	156 (20-1200)	136 (67-546)	0.968
AST, median (range)	74 (24-303)	76 (24-303)	55 (38-102)	0.533
ALP/AST ratio, median (range)	2.03 (0.625-7.64)	2.05 (0.625-7.64)	1.78 (1.40-2.21)	0.610
GGT, median (range)	165 (13-1838)	177 (12-1838)	73.5 (24-637)	0.275
Albumin, median (range)	39 (31-43)	39 (32-42)	40 (31-43)	0.810
Ferritin, median (range)	85 (7-913)	176 (45-913)	32.5 (7-79)	0.027a
Transferrin, median (range)	31.5 (23-42)	31.5 (23-42)	36 (30-41)	0.443
AMA	6 (35.3)	6 (54.5)	0 (0)	0.043a
AMA-M2	7 (100)	7 (100)	0 (0)	1.000
SMA	10 (52.6)	5 (41.7)	5 (71.4)	0.350
SMA-VGT	3 (15.8)	3 (25)	1 (14.3)	1.000
LKM-1	0 (0)	0 (0)	0 (0)	1.000
pANCA	4 (21.1)	2 (18.2)	2 (25)	1.000

^aP < 0.05.

^bP < 0.01.

LOS: Liver outcome score; AILDOS: All autoimmune liver disease overlap syndromes; AIH-PBC: Autoimmune hepatitis and primary biliary cholangitis overlap; AIH-PSC: Autoimmune hepatitis and primary sclerosing cholangitis overlap; MELD: Model for end-stage liver disease; MELD-Na: Model for end-stage liver disease incorporated with serum sodium score; WCC: White cell count; Hb: Hemoglobin; INR: International normalized ratio; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; AMA: Antimitochondrial antibody; SMA: Smooth muscle antibody; SMA-VGT: Smooth muscle antibody vascular glomerular tubular pattern; LKM-1: Liver kidney microsomal type 1 antibody; pANCA: Perinuclear antineutrophil cytoplasmic antibody.