Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis

Table 2 Forward mendelian randomization sensitivity analysis

Exposure panel	Exposure traits	Inverse variance weighted		MR-Egger
		Q value	P value	Intercept	P value
B cell	IgD- CD27-% lymphocyte	11.20	0.846	0.008	0.707
B cell	BAFF-R on IgD+ CD38- naive	19.98	0.831	0.002	0.880
B cell	CD20 on IgD+	18.76	0.407	-0.004	0.662
B cell	CD25 on memory B cell	21.52	0.549	-0.002	0.854
B cell	BAFF-R on CD20-	9.74	0.715	-0.005	0.795
B cell	CD25 on sw mem	17.72	0.541	0.004	0.771
B cell	CD38 on CD20-	14.73	0.680	0.012	0.521
Myeloid cell	HLA DR on CD33dim HLA DR+ CD11b+	25.66	0.266	-0.011	0.303
Myeloid cell	CD33 on basophil	29.56	0.101	0.014	0.248
Myeloid cell	CD33 on Mo MDSC	23.26	0.276	-0.007	0.490
Myeloid cell	CD33 on CD66b+ myeloid cell	18.20	0.376	-0.029	0.065
Myeloid cell	CD33 bright HLA DR+ CD14 dim% CD33 bright HLA DR+	29.63	0.197	0.011	0.294
Myeloid cell	CD33 on CD33 dim HLA DR-	18.45	0.427	0.018	0.184
Myeloid cell	CD33 on Im MDSC	30.80	0.077	0.013	0.354
Treg	CD39 on CD39+ secreting Treg	10.76	0.978	-0.005	0.554
Treg	CD28 on CD39+ resting Treg	21.59	0.423	0.013	0.220
Treg	CD28+ CD45 RA+ CD8 bright% T cell	80.46	0.676	0.009	0.252
TBNK	CD8 bright NKT AC	25.19	0.452	-0.014	0.225
TBNK	SSC-A on NK	27.35	0.198	0.004	0.771
cDC	CCR2 on CD62L+ myeloid DC	9.06	0.768	0.011	0.547

TBNK: T cells, B cells, and natural killer; cDC: Conventional dendritic cells; CD: Cluster of Differentiation; AC: Absolute count; BAFF: B-cell-activating factor; HLA: Human leukocyte antigen; MDSC: Myeloid-derived suppressor cells; NKT: Natural killer T cells; NK: Natural killer; CCR2: C-C motif chemokine receptor 2; SNPs: Single-nucleotide polymorphisms; IVs: Instrumental variables; MR: Mendelian randomization.