Causal association between 731 immunocyte phenotypes and liver cirrhosis: A bidirectional two-sample mendelian randomization analysis

Table 1 Number of single-nucleotide polymorphisms screened in each step

ID exposure	Panel	Immune traits	Number of SNPs after LD	Number of SNPs after F > 10	Number of final IVs
Ebi-a-GCST90001433	B cell	IgD- CD27-% lymphocyte	18	18	18
Ebi-a-GCST90001706	B cell	BAFF-R on IgD + CD38- naive	29	29	28
Ebi-a-GCST90001762	B cell	CD20 on IgD +	23	23	19
Ebi-a-GCST90001790	B cell	CD25 on memory B cell	27	27	24
Ebi-a-GCST90001830	B cell	BAFF-R on CD20-	14	14	14
Ebi-a-GCST90001793	B cell	CD25 on sw mem	21	21	20
Ebi-a-GCST90001809	B cell	CD38 on CD20-	20	20	19
Ebi-a-GCST90002110	Myeloid cell	HLA DR on CD33dim HLA DR + CD11b +	24	24	23
Ebi-a-GCST90001954	Myeloid cell	CD33 on basophil	23	23	22
Ebi-a-GCST90001952	Myeloid cell	CD33 on Mo MDSC	21	21	21
Ebi-a-GCST90001951	Myeloid cell	CD33 on CD66b + + myeloid cell	19	19	18
Ebi-a-GCST90001521	Myeloid cell	CD33 bright HLA DR + CD14 dim% CD33 bright HLA DR +	26	26	25
Ebi-a-GCST90001953	Myeloid cell	CD33 on CD33 dim HLA DR-	21	21	19
Ebi-a-GCST90001955	Myeloid cell	CD33 on Im MDSC	25	25	22
Ebi-a-GCST90002031	Treg	CD39 on CD39 + secreting Treg	24	24	23
Ebi-a-GCST90001901	Treg	CD28 on CD39 + resting Treg	23	23	22
Ebi-a-GCST90001688	Treg	CD28 + CD45 RA + CD8 bright% T cell	112	91	88
Ebi-a-GCST90001630	TBNK	CD8 bright NKT AC	27	27	26
Ebi-a-GCST90002076	TBNK	SSC-A on NK	24	24	23
Ebi-a-GCST90002014	cDC	CCR2 on CD62 L + myeloid DC	15	15	14

TBNK: T cells, B cells, and natural killer cells; ID: Identification; cDC: Conventional dendritic cells; CD: Cluster of differentiation; DR: Dweller region; AC: Absolute count; SSC-A: Side scatter-A; LD: Linkage disequilibrium; BAFF: B-cell-activating factor; HLA: Human leukocyte antigen; MDSC: Myeloid-derived suppressor cells; NKT: Natural killer T cells; NK: Natural killer; CCR2: C-C motif chemokine receptor 2; SNPs: Single-nucleotide polymorphisms; IVs: Instrumental variables.