Blood cell counts and nonalcoholic fatty liver disease: Evidence from Mendelian randomization analysis

Table 1 Characteristics of summary-level data used in the Mendelian randomization analysis

Phenotypes	Trait name	Unit	Sample size	No. of cases	Ethnicity	Adjustment	Ref.
Red blood cells	RBC	per pL	563946	545203	European	Age, sex, the first 10 principal components, and cohort-specific covariates were corrected in the original GWAS	[9]
	HGB	g/dL	563946	563946	European
	HCT	%	563946	562259	European
	MCH	pg	563946	491553	European
	MCV	fL	563946	544127	European
	MCHC	g/dL	563946	491553	European
	RDW	fL	563946	531774	European
Immature red cells	RET	pL	408112	408112	European		[10]
	RET%	%	408112	408112	European
White blood cells	WBC	per nL	563946	562243	European		[9]
	NEU	per nL	563946	519288	European
	LYM	per nL	563946	524923	European
	MONO	per nL	563946	521594	European
	BASO	per nL	563946	474001	European
	EO	per nL	563946	474237	European
Platelets	PLT	per nL	563946	542827	European
	MPV	fL	563946	460935	European
Covariates	WHR	SD	694649	694649	European	BMI	[27]
	T2D	Log (OR)	933970	80154	European	Age, sex, study-specific covariates, and principal components	[28]
Liver enzymes	ALP	SD	437438	437438	European	Age and sex and principal components of genetically inferred ancestry	[12]
	ALT	SD	437267	437267	European
	GGT	SD	437194	437194	European
	AST	SD	411048	411048	European	Age sex, BMI, and the first 12 principal components of genetic ancestry	[13]
Chronic liver diseases	NAFLD (Ghodsian et al[15], 2020)	Log (OR)	778614	8434	European	BMI	[15]
	NAFLD (Fingen 10)	Log (OR)	375002	2275	European	Age, sex, the first 10 genetic principal components, and genotyping batch	-

GWAS: Genome-wide association study; OR: Odds ratio; BMI: Body mass index; RBC: Red blood cell count; HGB: Haemoglobin concentration; HCT: Haematocrit; MCH: Mean corpuscular haemoglobin; MCV: Mean corpuscular volume; MCHC: Mean corpuscular haemoglobin concentration; RDW: Red cell distribution width; RET: Reticulocyte count; RET%: Reticulocyte fraction of red cells; WBC: White blood cell count; NEU: Neutrophil count; LYM: Lymphocyte count; MONO: Monocyte count; BASO: Basophil count; EO: Eosinophil count; PLT: Platelet count; MPV: Mean platelet volume; WHR: Waist-to-hip ratio; T2D: Type 2 diabetes; ALP: Alkaline phosphatase; ALT: Alanine aminotransferase; GGT: Gamma-glutamyl transferase; AST: Aspartate aminotransferase; NAFLD: Nonalcoholic fatty liver disease.