Tissue inhibitor of metalloproteinase-3 expression affects clinicopathological features and prognosis of aflatoxin B1-related hepatocellular carcinoma

Table 3 The risk effects of tissue inhibitor of metalloproteinase-3 expression in the cancerous tissues on the clinicopathological features of hepatocellular carcinoma

Risk effects	ORLTE/HTG1	95%CI	P value
Higher AFP	15.32	6.63-35.38	1.65 × 10-10
Higher tumor size	3.47	1.75-6.87	3.69 × 10-4
Tumor dedifferentiation	3.04	1.65-5.65	4.31 × 10-4
Higher TNM stage	2.60	1.64-4.07	4.21 × 10-5
Higher MVD	2.45	1.35-4.45	3.20 × 10-3
Higher risk of PVTT	4.38	2.18-8.83	3.52 × 10-4
Higher risk of MVI	3.24	1.71-6.14	3.20 × 10-4

¹OR_LTE/HTG represents the risk value of low TIMP3 expression (compared to high TIMP3 expression) on the knowledge clinicopathological features of hepatocellular carcinoma.

AFP: Alpha fetoprotein; TNM: Tumor node metastasis; MVD: Microvessel density; PVTT: Portal vein tumor thrombus; MVI: Microvessel infiltration; CI: Confidential interval; OR: Odds ratio.