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©The Author(s) 2024.
World J Hepatol. Aug 27, 2024; 16(8): 1099-1110
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1099
Published online Aug 27, 2024. doi: 10.4254/wjh.v16.i8.1099
Table 2 Factors associated with a nonalcoholic fatty liver disease fibrosis score value that does not exclude advanced fibrosis
Variable | Excluding advanced fibrosis (NFS < -1.455), n = 49 | Not excluding advanced fibrosis (NFS ≥ -1.455), n = 19 | P value | OR | 95%CI |
Sex, n (%) | 0.232 | 0.523 | 0.179-1.526 | ||
Female | 18 (36.7) | 10 (52.6) | |||
Male | 31 (63.3) | 9 (47.4) | |||
Age at diagnosis (yr), mean ± SD | 39 ± 16 | 57 ± 11 | < 0.001a | - | - |
Age (yr), median | 46 | 64 | < 0.001a | - | - |
BMI (kg/m2), mean ± SD | 26.1 ± 4.4 | 27.1 ± 4.9 | 0.409 | - | - |
Waist circumference (cm), median | 94 | 99 | 0.235 | - | - |
Arterial hypertension, n (%) | < 0.001a | 16.667 | 4.457-62.318 | ||
Yes | 9 (18.4) | 15 (78.9) | |||
No | 40 (81.6) | 4 (21.1) | |||
Type 2 DM, n (%) | 0.002a | 7.920 | 2.178-28.799 | ||
Yes | 5 (10.2) | 9 (47.4) | |||
No | 44 (89.8) | 10 (52.6) | |||
Dyslipidaemia, n (%) | 0.008a | 4.286 | 1.399-13.127 | ||
Yes | 14 (28.6) | 12 (63.2) | |||
No | 35 (71.4) | 7 (36.8) | |||
Obesity, n (%) | 0.329 | 2.051 | 0.613-6.863 | ||
Yes | 9 (18.4) | 6 (31.6) | |||
No | 40 (81.6) | 13 (68.4) | |||
Metabolic syndrome, n (%) | < 0.001a | 6.686 | 2.091-21.382 | ||
Yes | 10 (20.4) | 12 (63.2) | |||
No | 39 (79.6) | 7 (36.8) | |||
Regular alcohol intake, n (%) | 0.033a | 3.227 | 1.072-9.716 | ||
Yes | 17 (34.7) | 12 (63.2) | |||
No | 32 (65.3) | 7 (36.8) | |||
AAT value at diagnosis (mg/dL), median | 71 | 56 | 0.025a | - | - |
FEV1 (%), mean ± SD | 95 ± 27 | 93 ± 34 | 0.801 | - | - |
DLCO, mL of CO/s/mmHg, median | 95 | 88 | 0.225 | - | - |
- Citation: Ferreira AI, Guimarães C, Macedo Silva V, Xavier S, Magalhães J, Cotter J. Alpha-1 antitrypsin deficiency and Pi*Z allele as important co-factors in the development of liver fibrosis. World J Hepatol 2024; 16(8): 1099-1110
- URL: https://www.wjgnet.com/1948-5182/full/v16/i8/1099.htm
- DOI: https://dx.doi.org/10.4254/wjh.v16.i8.1099