Improvement of hepatic fibrosis after tenofovir disoproxil fumarate switching to tenofovir alafenamide for three years

Figure 1 Dynamics of mean alanine aminotransferase and aspartate aminotransferase reduction after tenofovir disoproxil fumarate switching to tenofovir alafenamide. The dynamic changes of mean alanine aminotransferase (ALT) and aspartate aminotransferase (AST) (U/L) including standard deviations are shown on the Y-axis. The time course of switching is shown on the X-axis. There was persistent improvement of mean ALT and AST reduction after switching from tenofovir disoproxil fumarate to tenofovir alafenamide up to week 144 (P < 0. 001). ALT: Alanine aminotransferase; AST: Aspartate aminotransferase.