Immunoprophylaxis failure and vaccine response in infants born to mothers with chronic hepatitis B infection in Djibouti

Table 4 Analysis of risk factors for failure of immunoprophylaxis

Variables	No failure, n = 48	Failure, n = 2	χ2	P value	OR (95%CI)	P value
HBV DNA of mother			32.64	< 0.001
> 200000 IU/mL	1 (2.1)	2 (100)			Reference
< 200000 IU/mL	47 (97.9)	0 (0)		-	158.00 (5.05-49.80)	0.004
Mother HBeAg status			32.64	< 0.001
Negative	47 (97.9)	0 (0)			Reference
Positive	1 (2.1)	2 (100)		-	158.00 (5.05-49.80)	0.004
Family history of HBV			1.07	0.300
No	31 (65.0)	2 (100)			Reference
Yes	17 (35.0)	0 (0)		-	0.36 (0.20-198.00)	0.517
History of abortion			0.89	0.340
No	33 (69.0)	2 (100)			Reference
Yes	15 (31.0)	0 (0)		-	0.43 (0.02-9.55)	0.595
Delivery mode in infants			0.59	0.440
Vaginal	37 (77.0)	2 (100)			Reference
Cesarean	11 (23.0)	0 (0)		-	1.50 (0.06-34.00)	0.780
Parity of mother			0.93	0.630
Null parous	7 (15.0)	0 (0)			Reference
Multiparous	30 (62.0)	1 (50.0)		-	0.73 (0.27-19.00)	0.181
Large multiparous	11 (23.0)	1 (50.0)		-	1.95 (0.07-54.00)	0.693
Infant birth weight			1.53	0.460
2.5-3.5 kg	35 (73.0)	1 (50.0)			Reference
< 2.5 kg	8 (17.0)	1 (50.0)		-	4.37 (0.25-77.65)	0.315
> 3.5 kg	5 (10.0)	0 (0)		-	2.15 (0.08-59.70)	0.651
Infant sex			1.17	0.280
Male	30 (62.0)	2 (100)			Reference
Female	18 (38.0)	0 (0)		-	0.54 (0.12-2.49)	0.428
Blood transfusion			0.50	0.490
No	35 (73.0)	1 (50.0)			Reference
Yes	13 (27.0)	1 (50.0)		-	2.69 (0.16-46.00)	0.495
First antenatal care of mother			3.70	0.157
1 trimester	16 (33.0)	0 (0)			Reference
2 trimester	16 (33.0)	0 (0)		-	0.02-53.40	1.000
3 trimester	16 (33.0)	2 (100)		-	5 (0.22-112.00)	0.310

Data are n (%). CI: Confidence interval; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus; OR: Odds ratio.