Successful treatment of severe hepatic impairment in erythropoietic protoporphyria: A case report and review of literature

Figure 1 Hepatic pathology and genetic screening. A and B: Liver histopathology demonstrates brown-yellow granule deposits in hepatocytes, capillary ducts, and Kupffer cells within the hepatic sinusoids. Enlarged portal area with increased lymphocyte and neutrophil infiltration, fibrous tissue hyperplasia, and hyperplasia of small bile ducts consistent with G3S3 chronic inflammatory liver injury; C and D: Genetic analysis reveals ferrochelatase gene mutations: homozygous intron c.315-48T>C mutation and heterozygous p.C202Y mutation. FECH: Ferrochelatase.