Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase

Figure 2 Liver histological changes in different clinical phases. A: Proportions of chronic hepatitis B patients in different clinical phases; B: The liver histological changes in different clinical phases using liver biopsy. Four phase including including immune tolerant phase, HBeAg-positive immune active phase, inactive phase, and HBeAg-negative immune active phase. ≥ G2 was defined by significant necroinflammation, ≥ S2 defined by significant fibrosis, and ≥ G2/S2 defined by significant histopathological changes.