Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase

Table 3 Predictors of liver histopathology changes in the indeterminate patients

	Univariable		Multivariable1
Significant necroinflammation	OR, (95%CI)	P value	Adjusted OR, (95%CI)	P value
Age, yr
< 40	Referent		Referent
≥ 40	1.29 (0.97, 1.72)	0.0846	1.75 (1.25, 2.44)	0.001
Sex
Male	Referent		Referent
Female	0.76 (0.54, 1.06)	0.1007	0.75 (0.52, 1.07)	0.1098
HBeAg
-	Referent		Referent
+	2.36 (1.72, 3.24)	< 0.0001	2.55 (1.77, 3.68)	< 0.0001
HBV-DNA log10, IU/mL
< 3	Referent		Referent
≥ 3	0.98 (0.63, 1.53)	0.9258	1.10 (0.67, 1.80)	0.7017
PLT, 109/L
> 150	Referent		Referent
≤ 150	3.16 (2.14, 4.66)	< 0.0001	2.77 (1.83, 4.19)	< 0.0001
ALT, U/L
< ULN	Referent		Referent
≥ ULN	1.85 (1.38, 2.49)	< 0.0001	1.60 (1.15, 2.25)	0.006
Significant fibrosis	OR, (95%CI)	P value	Adjusted OR, (95%CI)	P value
Age, yr
< 40	Referent		Referent
≥ 40	1.42 (1.07, 1.87)	0.0136	1.36 (1.00, 1.85)	0.049
Sex
Male	Referent		Referent
Female	0.88 (0.65, 1.20)	0.4272	0.97 (0.70, 1.35)	0.8752
HBeAg
-	Referent		Referent
+	1.08 (0.79, 1.47)	0.6367	1.14 (0.80, 1.62)	0.4734
HBV-DNA log10, IU/mL
< 3	Referent		Referent
≥ 3	0.85 (0.56, 1.31)	0.4636	0.93 (0.58, 1.49)	0.7537
PLT,109/L
> 150	Referent		Referent
≤ 150	4.30 (2.75, 6.71)	< 0.0001	3.92 (2.49, 6.17)	< 0.0001
ALT, U/L
< ULN	Referent		Referent
≥ ULN	1.27 (0.96, 1.68)	0.0907	1.15 (0.84, 1.59)	0.3758
Significant liver histological changes	OR, (95%CI)	P value	Adjusted OR, (95%CI)	P value
Age, yr
< 40	Referent		Referent
≥ 40	1.37 (1.03, 1.82)	0.0308	1.44 (1.06, 1.97)	0.0214
Sex
Male	Referent		Referent
Female	0.97 (0.71, 1.33)	0.8423	1.05 (0.76, 1.47)	0.7551
HBeAg
-	Referent		Referent
+	1.41 (1.03, 1.95)	0.0347	1.40 (0.97, 2.01)	0.0689
HBV-DNA log10, IU/mL
< 3	Referent		Referent
≥ 3	0.97 (0.63, 1.49)	0.8813	1.13 (0.70, 1.81)	0.626
PLT,109/L
> 150	Referent		Referent
≤ 150	3.34 (2.09, 5.35)	< 0.0001	2.99 (1.85, 4.83)	< 0.0001
ALT, U/L
< ULN	Referent		Referent
≥ ULN	1.57 (1.19, 2.09)	0.0016	1.48 (1.08, 2.05)	0.0163

¹Adjusted for age, sex, alanine aminotransferase level, HBeAg statue, platelet level, and hepatitis B virus DNA level.

HBV: Hepatitis B virus; ALT: Alanine aminotransferase; GGT: Glutamate aminotransferase; PLT: Platelet; ULN: Upper limits of normal.