Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase

Table 2 Clinical characteristics of different indeterminate phase chronic hepatitis B, n (%)

Phase	Indeterminate-A	Indeterminate-B	Indeterminate-C	Indeterminate-D	P value
N	62 (7.62)	160 (19.66)	304 (37.35)	288 (35.38)
Age, yr	36.42 ± 7.56	34.30 ± 7.70	40.93 ± 8.08	40.56 ± 9.05	< 0.001
Male	46 (74.19)	111 (69.38)	211 (69.41)	230 (79.86)	0.019
HBsAg, log10, IU/mL	3.58 ± 0.81	4.12 ± 0.79	2.99 ± 0.73	2.77 ± 1.08	< 0.001
HBeAg					< 0.001
Negative	0 (0.00)	0 (0.00)	304 (100.00)	288 (100.00)
Positive	62 (100.00)	160 (100.00)	0 (0.00)	0 (0.00)
HBV-DNA, log10, IU/mL	4.33 ± 1.22	7.03 ± 1.72	4.28 ± 0.79	3.88 ± 1.40	< 0.001
ALT, (IQR), U/L	24.00 (18.25-28.00)	45.00 (38.00-55.00)	21.00 (16.00-26.00)	43.00 (37.00-57.25)	< 0.001
AST, (IQR), U/L	23.00 (20.00-26.38)	32.00 (27.80-40.00)	21.00 (18.00-24.00)	29.50 (25.00-38.00)	< 0.001
GGT, (IQR), U/L	20.00 (16.00-32.80)	32.15 (18.00-53.25)	19.00 (14.00-25.23)	32.00 (21.75-49.25)	0.167
TBIL, (IQR), umol/L	13.10 (8.98-16.71)	13.55 (10.50-17.42)	12.55 (9.70-16.35)	12.90 (10.07-17.72)	< 0.001
ALB, g/L	43.83 ± 4.28	43.96 ± 4.05	44.71 ± 3.65	44.73 ± 3.98	0.144
WBC, 109/L	6.14 ± 1.64	5.70 ± 1.49	5.76 ± 1.61	5.96 ± 1.62	0.085
PLT, 109/L	207.32 ± 69.37	203.07 ± 59.53	210.12 ± 55.75	202.57 ± 60.84	0.477
APRI stage					< 0.001
< 1	59 (95.16)	145 (90.62)	301 (99.01)	268 (93.06)
2	2 (3.23)	9 (5.62)	3 (0.99)	6 (2.08)
> 2	1 (1.61)	6 (3.75)	0 (0.00)	14 (4.86)
FIB-4 stage					0.136
< 1.45	49 (79.03)	131 (81.88)	257 (84.54)	225 (78.12)
1.45- 3.25	10 (16.13)	21 (13.12)	43 (14.14)	47 (16.32)
> 3.25	3 (4.84)	8 (5.00)	4 (1.32)	16 (5.56)
GPR stage					< 0.001
≤ 0.32	42 (67.74)	75 (46.88)	247 (81.25)	133 (46.18)
> 0.32	20 (32.26)	85 (53.12)	57 (18.75)	155 (53.82)
Stage of inflammation					< 0.001
0	4 (6.45)	2 (1.25)	4 (1.32)	4 (1.39)
1	23 (37.10)	80 (50.00)	231 (75.99)	172 (59.72)
2	28 (45.16)	67 (41.88)	68 (22.37)	100 (34.72)
3	7 (11.29)	10 (6.25)	0 (0.00)	9 (3.12)
4	0 (0.00)	1 (0.62)	1 (0.33)	3 (1.04)
Degree of fibrosis					< 0.001
0	2 (3.23)	2 (1.25)	6 (1.97)	7 (2.43)
1	23 (37.10)	81 (50.62)	164 (53.95)	122 (42.36)
2	12 (19.35)	34 (21.25)	89 (29.28)	84 (29.17)
3	8 (12.90)	16 (10.00)	33 (10.86)	39 (13.54)
4	17 (27.42)	27 (16.88)	12 (3.95)	36 (12.50)
≥ G2	35 (56.45)	78 (48.75)	69 (22.70)	112 (38.89)	< 0.001
≥ S2	37 (59.68)	77 (48.12)	134 (44.08)	159 (55.21)	0.019
G2/S2	41 (66.13)	105 (65.62)	156 (51.32)	186 (64.58)	0.002

IQR: Interquartile range; HBV: Hepatitis B virus; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Glutamate aminotransferase; TBIL: Total bilirubin; ALB: Albumin; WBC: White blood cell; PLT: Platelet; APRI: Aspartate aminotransferase-to-platelet ratio index; FIB-4: Fibrosis-4 index; GPR: Gamma- glutamyl- transpeptidase to platelet ratio.