Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase

Table 1 Clinical characteristics of chronic hepatitis B patients in the different phases, n (%)

Phase	Immune-Tolerant CHB	HBeAg-positive immune active CHB	Inactive CHB	HBeAg-negative Immune Active CHB	Indeterminate	P value
N	118 (7.70)	197 (12.86)	317 (20.70)	86 (5.61)	814 (53.13)
Age, yr	33.11 ± 7.52	32.41 ± 7.15	40.13 ± 9.37	40.43 ± 9.48	39.15 ± 8.73	< 0.001
Male	53 (44.92)	131 (66.50)	222 (70.03)	68 (79.07)	598 (73.46)	< 0.001
HBsAg, log10, IU/mL	4.62 ± 0.59	4.18 ± 0.73	2.38 ± 1.26	3.28 ± 0.65	3.18 ± 1.02	< 0.001
HBeAg						< 0.001
Negative	0 (0.00)	0 (0.00)	317 (100.00)	86 (100.00)	592 (72.73)
Positive	118 (100.00)	197 (100.00)	0 (0.00)	0 (0.00)	222 (27.27)
HBV-DNA, log10, IU/mL	8.03 ± 0.54	7.60 ± 1.01	2.47 ± 0.56	5.68 ± 1.40	4.71 ± 1.73	< 0.001
ALT, (IQR), U/L	19.00 (15.00-23.00)	138.00 (88.00-233.00)	18.00 (14.00-25.00)	106.50 (79.00-245.00)	33.00 (23.00-45.00)	< 0.001
AST, (IQR), U/L	20.00 (17.00-22.75)	74.00 (50.00-129.00)	20.00 (17.00-23.00)	57.00 (42.25-108.00)	26.00 (21.00-33.00)	< 0.001
GGT, (IQR), U/L	15.00 (12.00-20.00)	52.00 (29.00-89.00)	18.00 (14.00-27.00)	50.50 (34.25-80.25)	25.00 (17.00-40.00)	< 0.001
TBIL, (IQR), umol/L	11.25 (8.20-14.47)	15.20 (10.90-21.60)	12.40 (9.30-16.70)	15.60 (11.83-21.20)	12.75 (9.90-17.30)	< 0.001
ALB, g/L	44.53 ± 3.42	42.52 ± 4.26	44.85 ± 3.23	43.57 ± 5.68	44.50 ± 3.91	< 0.001
WBC, 109/L	5.62 ± 1.24	5.55 ± 1.59	5.69 ± 1.44	5.85 ± 1.97	5.85 ± 1.60	0.062
PLT, 109/L	228.04 ± 58.84	198.12 ± 54.38	204.09 ± 57.04	200.98 ± 65.66	205.85 ± 59.42	< 0.001
Stage of Inflammation						< 0.001
0	2 (1.69)	0 (0.00)	11 (3.47)	0 (0.00)	14 (1.72)
1	90 (76.27)	31 (15.74)	271 (85.49)	23 (26.74)	506 (62.16)
2	26 (22.03)	113 (57.36)	33 (10.41)	48 (55.81)	263 (32.31)
3	0 (0.00)	51 (25.89)	2 (0.63)	15 (17.44)	26 (3.19)
4	0 (0.00)	2 (1.02)	0 (0.00)	0 (0.00)	5 (0.61)
Degree of fibrosis						< 0.001
0	3 (2.54)	5 (2.54)	14 (4.42)	1 (1.16)	17 (2.09)
1	82 (69.49)	72 (36.55)	181 (57.10)	28 (32.56)	390 (47.91)
2	29 (24.58)	65 (32.99)	80 (25.24)	32 (37.21)	219 (26.90)
3	4 (3.39)	31 (15.74)	25 (7.89)	8 (9.30)	96 (11.79)
4	0 (0.00)	24 (12.18)	17 (5.36)	17 (19.77)	92 (11.30)
≥ G2	26 (22.03)	166 (84.26)	35 (11.04)	63 (73.26)	294 (36.12)	< 0.001
≥ S2	33 (27.97)	120 (60.91)	122 (38.49)	57 (66.28)	407 (50.00)	< 0.001
G2/S2	44 (37.29)	171 (86.80)	129 (40.69)	71 (82.56)	488 (59.95)	< 0.001

IQR: Interquartile range; HBV: Hepatitis B virus; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; GGT: Glutamate aminotransferase; TBIL: Total bilirubin; ALB: Albumin; WBC: White blood cell; PLT: Platelet; CHB: Chronic hepatitis B.