In-hospital outcomes in COVID-19 patients with non-alcoholic fatty liver disease by severity of obesity: Insights from national inpatient sample 2020

Table 2 Multivariable odds of in-hospital outcomes in obese coronavirus disease 2019 hospitalizations with non-alcoholic fatty liver disease

	Obesity II vs I	Obesity III vs I	Obesity I vs overweight
Outcomes	aOR [LL-UL]	aOR [LL-UL]	aOR [LL-UL]	P value
MACCE	1.19 [0.78-1.81]	1.82 [1.22-2.73]	1.66 [0.92-2.98]	0.016
Death during hospitalization	1.10 [0.69-1.76]	1.96 [1.23-3.11]	1.59 [0.84-3.02]	0.015
Acute myocardial infarction	1.91 [0.77-4.72]	2.32 [0.92-5.88]	1.72 [0.53-5.57]	0.346
Cardiac arrest	1.14 [0.49-2.67]	1.25 [0.56-2.80]	0.60 [0.13-2.78]	0.782
Acute ischemic stroke	0.23 [0.04-1.28]	0.36 [0.06-2.02]	5.52 [0.55-55.56]	0.130
Respiratory failure	1.27 [0.99-1.61]	1.35 [1.07-1.70]	0.97 [0.67-1.41]	0.049
Mechanical ventilation	0.90 [0.63-1.31]	1.34 [0.97-1.85]	1.01 [0.58-1.75]	0.095
	I vs overweight	II vs overweight	III vs overweight
Outcomes	aOR [LL-UL]	aOR[LL-UL]	aOR[LL-UL]	P value
MACCE	0.60 [0.34-1.08]	0.72 [0.39-1.32]	1.10 [0.62-1.95]	0.016
Death during hospitalization	0.63 [0.33-1.19]	0.69 [0.35-1.35]	1.23 [0.66-2.30]	0.015
Respiratory failure	1.04 [0.71-1.51]	1.28 [0.88-1.88]	1.40 [0.96-2.04]	0.057
Mechanical ventilation	0.99 [0.57-1.72]	0.90 [0.51-1.59]	1.33 [0.78-2.27]	0.095

Overweight BMI 25-29.9; Class I Obesity BMI 30-34.9; Class II Obesity BMI 35-39.9; Class III Obesity BMI 40 or higher. Multivariable regression models were adjusted for age at admission, sex, race, income quartile for patient’s ZIP code, type of admission, hospital location/teaching status, hypertension, diabetes, hyperlipidemia, peripheral vascular disease, tobacco use disorder, prior MI, prior TIA/Stroke, cancer, CKD and Bariatric surgery status. aOR: Adjusted odds ratio; LL: Lower limit, UL: Upper limit; MACCE: Major adverse cardiac and cerebrovascular events.