Presepsin as a biomarker of bacterial translocation and an indicator for the prescription of probiotics in cirrhosis

Table 3 Change in the values of the main cirrhosis indicators as a result of the probiotic (Saccharomyces boulardii) taking, depending on the baseline presepsin level, n (%)

	Elevated baseline presensin level (n = 13)			Normal baseline presensin level (n = 9)
	At the beginning of the study	After the probiotic course	P value	At the beginning of the study	After the probiotic course	P value
Child–Pugh score	9 (8-11)	7 (6-9)	0.004	8 (7-8)	7 (6-8)	0.124
Child–Pugh class, A/B+C	0/13	5/8	0.020	0/9	2/7	0.235
No hepatic encephalopathy	2 (15.4)	8 (61.5)	0.021	2 (22.2)	3 (33.3)	0.500
Ascites	12 (92.3)	5 (38.4)	0.006	8 (88.9)	5 (55.5)	0.147
Serum albumin, g/L	32 (30-34)	33 (32-39)	0.033	35 (33-36)	38 (37-39)	0.008
Serum total bilirubin, μmol/L	52 (36-120)	29 (26-40)	0.016	34 (26-44)	25 (22-35)	0.066
Alanine aminotransferase, U/L	26 (18-47)	26 (18-40)	0.272	30 (21-41)	33 (25-39)	0.813
Aspartate aminotransferase, U/L	60 (37-75)	39 (27-51)	0.012	45 (28-51)	36 (36-42)	0.314
Gamma glutamyl transferase, U/L	92 (44-207)	56 (40-89)	0.196	37 (31-317)	62 (30-115)	0.193
Alkaline phosphatase, U/L	268 (245-355)	210 (187-245)	0.013	261 (227-446)	215 (188-275)	0.110