Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

doi:10.4254/wjh.v16.i5.809

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May 27, 2024 (publication date) through Jul 23, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Prospective Study

World J Hepatol. May 27, 2024; 16(5): 809-821
Published online May 27, 2024. doi: 10.4254/wjh.v16.i5.809

Table 1 Etiological characteristics of 3375 acute-on-chronic liver disease patients, n (%)

Characteristic	Overall (n = 3375)	Noncirrhosis (n = 792)	Cirrhosis (n = 2853)	P value
Demographics
Sex, male	2489 (73.7)	606 (76.5)	1883 (72.9)	0.048
Age, yr (mean ± SD)	49.65 ± 12.14	42.51 ± 11.65	51.84 ± 11.43	< 0.001
Etiology
HBV	2409 (71.4)	691 (87.2)	1718 (66.5)	< 0.001
HCV	126 (3.7)	11 (1.4)	115 (4.5)	< 0.001
ALD	649 (19.2)	100 (12.6)	549 (21.3)	< 0.001
AILD	308 (9.1)	39 (4.9)	269 (10.4)	< 0.001
MAFLD	104 (3.1)	69 (8.7)	35 (1.4)	< 0.001
DILD	58 (1.7)	25 (3.2)	33 (1.3)	0.001
MLD	7 (0.2)	2 (0.3)	5 (0.2)	1
Schistosomiasis	49 (1.5)	4 (0.5)	45 (1.7)	0.017
Cryptogenic	169 (5.0)	10 (1.3)	159 (6.2)	< 0.001

HBV: Hepatitis B virus; HCV: Hepatitis C virus; ALD: Alcohol-associated liver disease; MAFLD: Metabolic-associated fatty liver disease; DILD: Drug-induced liver disease; AILD: Autoimmune liver disease; MLD: Metabolic liver disease.

Citation: Zhang YY, Luo S, Li H, Sun SN, Wang XB, Zheng X, Huang Y, Li BL, Gao YH, Qian ZP, Liu F, Lu XB, Liu JP, Ren HT, Zheng YB, Yan HD, Deng GH, Qiao L, Zhang Y, Gu WY, Xiang XM, Zhou Y, Hou YX, Zhang Q, Xiong Y, Zou CC, Chen J, Huang ZB, Jiang XH, Qi TT, Chen YY, Gao N, Liu CY, Yuan W, Mei X, Li J, Li T, Zheng RJ, Zhou XY, Zhao J, Meng ZJ. Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study. World J Hepatol 2024; 16(5): 809-821
URL: https://www.wjgnet.com/1948-5182/full/v16/i5/809.htm
DOI: https://dx.doi.org/10.4254/wjh.v16.i5.809