Characteristics of patients with Wilson disease in the United States: An insurance claims database study

Table 4 Mortality

	Insurees with WD			All insurees
Year	Total n	Deaths	Mortality rate, %	Total n	Deaths	Mortality rate, %
20161	1887	27	1.43	203060882	1991215	0.98
2017	2239	51	2.28	223313801	2341297	1.05
2018	2253	58	2.57	223828962	2420297	1.08
2019	2356	61	2.59	219088011	2390049	1.09
2020	2220	63	2.84	215457629	2461627	1.14
20212	2277	13	0.57	239164264	205313	0.09
Total	5376	273	5.08	431039425	11809798	2.74

¹2016 was the first full year in which the specific International Classification of Diseases 10 (ICD-10) code for Wilson disease (WD) was used as a claim label in the Clarivate clearinghouse. Because two successive claims with an ICD-10 code for WD are required for case identification, it is possible that the number of incident cases in 2016 was underestimated.

²As there is a lag time before all deaths are uploaded into the clearinghouse from death registries, the number of deaths documented for 2021 will be underestimated.