Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease

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May 27, 2024 (publication date) through Nov 12, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. May 27, 2024; 16(5): 703-715
Published online May 27, 2024. doi: 10.4254/wjh.v16.i5.703

Table 3 Effect of histone methylation on hepatic fibrosis

Histone methylation	Functions	Effects on fibrosis	Ref.
H3K9me1/2/3↑	(Upstream) (-) Transcription initiation	Expression of PPARγ↓	[67,69,70]
H3K9me1/2/3↑	(Upstream) (-) Transcription initiation	Hepatic Fibrosis↑	[67,69,70]
H3K27me1/2/3↑	(Downstream) (-) Transcriptional extensions	Expression of PPARγ↓	[67,69,70]
H3K27me1/2/3↑	(Downstream) (-) Transcriptional extensions	Hepatic Fibrosis↑	[67,69,70]
H3K4me2/3↑	(The whole process) (+) Genes for fibrosis (TGF-β1, TIMP-1, α-SMA and Collagen type I)	Hepatic Fibrosis↑	[67,69,70]
H3K36me3↑		Hepatic Fibrosis↑	[67,69,70]

Citation: Xu L, Fan YH, Zhang XJ, Bai L. Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease. World J Hepatol 2024; 16(5): 703-715
URL: https://www.wjgnet.com/1948-5182/full/v16/i5/703.htm
DOI: https://dx.doi.org/10.4254/wjh.v16.i5.703