Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease

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May 27, 2024 (publication date) through Jan 27, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. May 27, 2024; 16(5): 703-715
Published online May 27, 2024. doi: 10.4254/wjh.v16.i5.703

Table 2 Effect of histone methylation on inflammatory injury

Histone methylation	HMTs/HDMs	Mechanisms	Effects on Inflammatory Injury	Ref.
H3K4me3↑	SET7/9/KMT7	(+) SET7/9→promoter (TNF-α→Pro-inflammatory genes) ←NF-κB p65	Inflammatory reaction↑	[58]
H3K79me1/2/3↑	DOT1L	(+) DOT1L→Pathways of SREBP→ (-) Inflammatory expression of macrophages	Inflammatory reaction↓	[49]
H3R2me3↑	PRMT5	(+) PRMT5→promoter (OXR1A) →Growth Hormone	Oxidation stress↑	[64,65]
H3K27me3↓	JMJD3/KDM6B	In case of non-diabetic injury: (+) IFN-β→JAK1/3-STAT3→JMJD3→STING-TBK1/IRF3/IFN-α	In case of non-diabetic injury:Wound Recovery	[59-63]
H3K27me3↓	JMJD3/KDM6B	In case of diabetic injury: (-) IL-6→JAK1/3-STAT3→JMJD3→IFN-α; (+) IL-6→JAK1/3-STAT3→JMJD3→NF-κB	In case of diabetic injury:Inflammatory reaction↑	[59-63]

HMTs: Histone methyltransferases; HDMs: Histone demethylases; TNF-α: Tumor necrosis factor-α.

Citation: Xu L, Fan YH, Zhang XJ, Bai L. Unraveling the relationship between histone methylation and nonalcoholic fatty liver disease. World J Hepatol 2024; 16(5): 703-715
URL: https://www.wjgnet.com/1948-5182/full/v16/i5/703.htm
DOI: https://dx.doi.org/10.4254/wjh.v16.i5.703