Molecular mechanism of nanomaterials induced liver injury: A review

Table 7 Effects and molecular mechanisms underlying MgONPs induced hepatonanotoxicity

NPs	Size	Tested model	Dose & route of administration	Effects & mechanism	Ref.
MgO	-	3D Human Liver organoids male Sprauge Dawley rat	100 μg/mL incubated for 48 h. 40 mg/kg daily for 4 wk (oral)	ATP synthesis (decreased); ROS & Super oxide production (increased); ALT, AST (increased)	[21]
				Oxidative stress

ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; ATP: Adenosine triphosphate; ROS: Reactive oxygen species.