Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

Table 6 Association between genetic polymorphism and metabolic traits

Genetic polymorphisms	Metabolic traits
	FPG (mg/dL), n = 175		HbA1C (mmol/L), n = 159		AST (U/L), n = 175		ALT (U/L), n = 177
	< 100	≥ 100	< 6.5	≥ 6.5	< 34	≥ 34	< 40	≥ 40
PNPLA3 rs738409 (CC vs CG+GG)
OR (95%CI)	0.354 (0.063-1.984)		1.055 (0.437-2.543)		2.568 (1.243-5.305)		1.679 (0.713-3.953)
P value	0.219		0.906		0.010a		0.232
APOC3 rs2854116 (TT vs CT+CC)
OR (95%CI)	0.956 (0.923-0.991)		1.553 (0.495-4.897)		0.735 (0.335-1.614)		0.630 (0.253-1.570)
P value	0.342		0.448		0.442		0.318
APOA5 rs662799 (AA + AG+GG)
OR (95%CI)	1.167 (0.229-5.946)		1.213 (0.509-2.893)		0.823 (0.421-1.611)		0.730 (0.320-1.664)
P value	1.000		0.663		0.570		0.453
APOB rs10495712 (GG vs AG+AA)
OR (95%CI)	1.100 (0.123-9.802)		1.150 (0.356-3.720)		2.063 (0.879-4.840)		1.255 (0.431-3.651)
P value	0.923		0.815		0.092		0.774
LIPC rs1800588 (CC vs CT+TT)
OR (95%CI)	0.947 (0.907-0.989)		1.709 (0.636-4.592)		1.476 (0.719-3.027)		2.208 (0.844-5.776)
P value	0.093		0.284		0.287		0.100
LEP rs7799039 (GG vs AG+AA)
OR (95%CI)	0.268 (0.046-1.561)		1.008 (0.272-3.746)		1.329 (0.462-3.827)		2.016 (0.444-9.155)
P value	0.166		1.000		0.579		0.535
GHRL rs27647 (AA vs AG+GG)
OR (95%CI)	1.045 (1.009-1.083)		0.700 (0.222-2.206)		0.676 (0.285-1.605)		0.795 (0.280-2.256)
P value	0.345		0.541		0.373		0.666

^aP value < 0.05. AST: Aspartate aminotransaminase; ALT Alanine aminotransaminase; OR: Odds ratio; FPG: Fasting plasma glucose; HbA1C: Hemoglobin A1C.