Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

Table 5 Association between genetic polymorphism and Lipid profile

Genetic polymorphisms	Lipid parameters
	Triglyceride (mg/dL), (n = 177)		Total cholesterol (mg/dL), (n = 177)		LDL-cholesterol (mg/dL), (n = 177)		HDL-cholesterol (mg/dL), (n = 66)	HDL-cholesterol (mg/dL), (n = 111)
	< 150	≥ 150	< 200	≥ 200	< 130	≥ 130	Men ≥ 40 mg/dL, women ≥ 50 mg/dL	Men < 40 mg/dL, women < 50 mg/dL
PNPLA3 rs738409 CC vs CG+GG
OR (95%CI)	0.699 (0.383-1.277)		1.053 (0.580-1.912)		1.088 (0.597-1.981)		0.9967 (0.538 -1.846)
P value	0.243		0.865		0.784		0.992
APOC3 rs2854116 TT vs CT+CC
OR (95%CI)	0.796 (0.387-1.635)		1.611 (0.780-3.328)		1.173 (0.568-2.423)		0.4696 (0.253-0.873)
P value	0.534		0.195		0.666		0.017a
APOA5 rs662799 AA vs AG+GG
OR (95%CI)	1.021 (0.562-1.855)		0.543 (0.299-0.989)		0.595 (0.326-1.084)		0.739 (0.374-1.461)
P value	0.946		0.045a		0.089		0.385
APOB rs10495712 (GG vs AG+AA)
OR (95%CI)	0.749 (0.322-1.743)		0.719 (0.315-1.639)		0.807 (0.351-1.855)		0.816 (0.343-1.938)
P value	0.501		0.431		0.613		0.645
LIPC rs1800588 CC vs CT+TT
OR (95%CI)	0.870 (0.467-1.621)		0.732 (0.393-1.363)		0.607 (0.326-1.132)		0.911 (0.482-1.722)
P value	0.661		0.325		0.115		0.774
LEP rs7799039 GG vs AG+AA
OR (95%CI)	9.316 (2.064-40.428)		1.623 (0.655-4.017)		1.518 (0.602-3.825)		1.317 (0.507-3.419)
P value	0.001a		0.292		0.374		0.572
GHRL rs27647 (AA vs AG+GG)
OR (95%CI)	0.570 (0.265-1.224)		0.997 (0.483-2.058)		0.905 (0.436-1.878)		0.889 (0.417-1.895)
P value	0.147		0.993		0.788		0.761

^aP < 0.05 compare between normal level vs abnormal level. OR: Odds ratio; HDL: High-density lipoprotein; LDL: Low-density lipoprotein.