Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

doi:10.4254/wjh.v16.i3.366

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 16, Issue 3

This Article

Academic Content and Language Evaluation of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Supplementary Materials of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (3145)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-1) series, Tables (1-7) series.

Item

Count

PDF

HTML

1402

Figures (1-1)

189

Tables (1-7)

152

Sum=1811

Featured Article

The chart showing Browse series, Download series.

Item

Count

Browse

268

Download

565

Sum=833

Publishing Process of This Article

Item

Count

Browse

Download

359

Sum=420

Mar 27, 2024 (publication date) through Dec 25, 2024

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Hepatology

ISSN

1948-5182

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Case Control Study

World J Hepatol. Mar 27, 2024; 16(3): 366-378
Published online Mar 27, 2024. doi: 10.4254/wjh.v16.i3.366

Table 3 Genotype and allele frequencies of the single-nucleotide polymorphisms in the people living with human immunodeficiency virus and metabolic-associated fatty liver disease compared with people living with human immunodeficiency virus and non-metabolic-associated fatty liver disease group

Gene	SNP	B allele	Dominant model				Recessive model
			PLWH and MAFLD vs PLWH and non-MAFLD		PLWH and MAFLD vs Chinese Dai		PLWH and MAFLD vs PLWH and non-MAFLD		PLWH and MAFLD vs Chinese Dai
			OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value	OR (95%CI)	P value
PNPLA3	rs738409	G	1.476 (0.809-2.694)	0.204	2.539 (1.382-4.665)	0.002^b	0.94 (0.276-3.202)	0.921	0.929 (0.273-3.166)	0.907
APOC3	rs2854116	C	1.117 (0.543-2.297)	0.764	1.203 (0.588-2.462)	0.613	0.798 (0.411-1.550)	0.506	0.828 (0.425-1.614)	0.579
LEP	rs7799039	G	0.704 (0.287-1.727)	0.422	0.408 (0.146-1.142)	0.080	0.886 (0.491-1.601)	0.689	0.730 (0.403-1.322)	0.298
GHRL	rs27647	G	0.466 (0.217-1.001)	0.047^a	0.704 (0.317-1.566)	0.388	2.146 (1.832-2.514)	0.469	2.134 (1.823-2.499)	0.472
LIPC	rs1800588	T	1.506 (0.806-2.815)	0.198	1.676 (0.898-3.128)	0.104	1.053 0.452-2.456)	0.905	1.040 (0.446-2.427)	0.928
APOB	rs10495712	A	1.264 (0.557-2.871)	0.575	2.156 (0.855-5.436)	0.098	1.134 (0.070-18.422)	1.000	2.134 (1.823-2.499)	0.472
APOA5	rs662799	G	0.914 (0.505-1.654)	0.766	0.960 (0.330-2.790)	0.940	0.629 (0.177-2.231)	0.470	0.734 (0.200-2.697)	0.751

Data expressed as OR odds ratio, CI confidence interval.

^aP value < 0.05 compared between people living with human immunodeficiency virus (PLWH) and metabolic-associated fatty liver disease (MAFLD) vs PLWH and non-MAFLD.

^bP value < 0.05 compared between PLWH and MAFLD vs Chinese Dai was represented as general population, B-allele expressed risk allele. MAFLD: Metabolic-associated fatty liver disease; PLWH: People living with human immunodeficiency virus; SNP: Single-nucleotide polymorphism.

Citation: Choochuay K, Kunhapan P, Puangpetch A, Tongsima S, Srisawasdi P, Sobhonslidsuk A, Sungkanuparph S, Biswas M, Sukasem C. Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus. World J Hepatol 2024; 16(3): 366-378
URL: https://www.wjgnet.com/1948-5182/full/v16/i3/366.htm
DOI: https://dx.doi.org/10.4254/wjh.v16.i3.366