Associations of PNPLA3 and LEP genetic polymorphisms with metabolic-associated fatty liver disease in Thai people living with human immunodeficiency virus

Table 2 Genotype distributions and Minor allele frequency of candidates single-nucleotide polymorphisms

Polymorphism	PLWH and MAFLD (n = 83)	PLWH and non-MAFLD (n = 94)	P value	MAFLD (n = 145)	Chinese Dai (n = 94)	P value
PNPLA3 rs738409
MAF = G	57 (34.33)	56 (29.78)	0.413	92 (31.73)	43 (23.12)	0.035a
APOC3 rs2854116
MAF=T	81 (47.09)	87(46.28)	0.691	128 (44.14)	88 (47.31)	< 0.001b
LEP rs7799039
MAF=G	57 (33.14)	57 (30.32)	0.738	85 (29.31)	48 (25.81)	0.674
GHRL rs27647
MAF = C	13 (7.56)	25 (13.30)	0.055	28 (9.66)	18 (9.68)	0.702
LIPC rs1800588
MAF = T	70 (42.17)	70 (37.33)	0.421	101 (34.83)	67 (36.02)	0.872
APOB rs10495712
MAF = A	15 (8.06)	14 (7.45)	0.853	22 (7.59)	8 (4.30)	0.339
APOA5 rs662799
MAF = G	41 (22.04)	51 (27.13)	0.766	75 (25.86)	52 (27.96)	0.834

^aP value < 0.05 compared between people living with human immunodeficiency virus (PLWH) and metabolic-associated fatty liver disease (MAFLD) vs PLWH and non-MAFLD.

^bP value < 0.05 compared between PLWH and MAFLD vs MAFLD MAF minor allele frequency, Chinese Dai was represented as general population. Data represented as n (%), PLWH and MAFLD vs other groups, differences between groups were tested by Chi-square test. MAFLD: Metabolic-associated fatty liver disease; PLWH: People living with human immunodeficiency virus; MAF: Metabolic-associated fatty.