Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents

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Mar 27, 2024 (publication date) through Nov 13, 2024

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Mar 27, 2024; 16(3): 331-343
Published online Mar 27, 2024. doi: 10.4254/wjh.v16.i3.331

Table 1 Novel therapeutic agents for treatment of chronic hepatitis B infection in phase II or III development

Drug name (therapeutic class)	Drug sponsor	Phase
Core/capsid inhibitors
JNJ56136379 (JNJ-6379)	Janssen Pharmaceutics	II
ABI-H0731 (Vebicorvir)	Assembly Biosciences	II
Entry inhibitors
Bulevirtide (Hepcludex, formerly Myrcludex)	Gilead Sciences	III
Small interfering RNA
GSK3228836 (Bepirovirsen)	Ionis Pharmaceuticals	III
VIR-2218	Vir Biotechnology	II
VIR-3314	Vir Biotechnology	II
JNJ-73753989 (JNJ-3989, formerly ARO-HBV)	GlaxoSmithKline Pharmaceuticals	II
Arbutus-729 (AB-729 or Imdusiran)	Arbutus Biopharma	II
HBsAg inhibition
REP 2139/REP 2165	Replicor	II
Toll-like receptor agonists
GS-9620 (Vesatolimod)	Gilead Sciences	II
GS-9688 (Selgantolimod)	Gilead Sciences	II
Therapeutic vaccines
GS-4774	Gilead Sciences	II
BRII-179	Brii Biosciences	II

Citation: Lam R, Lim JK. Advances in discovery of novel investigational agents for functional cure of chronic hepatitis B: A comprehensive review of phases II and III therapeutic agents. World J Hepatol 2024; 16(3): 331-343
URL: https://www.wjgnet.com/1948-5182/full/v16/i3/331.htm
DOI: https://dx.doi.org/10.4254/wjh.v16.i3.331