Autoimmune hepatitis and primary sclerosing cholangitis after direct-acting antiviral treatment for hepatitis C virus: A case report

Figure 1 Initial and second liver biopsy. A and B: The initial liver biopsy showing inflammatory cell infiltration mainly composed of lymphocytes and plasma cells in the portal and lobular areas, and severe interface hepatitis with rosette formation. Hematoxylin and eosin staining (HE: A, × 100; B, × 200); C and D: A second liver biopsy shows improvement of the interface hepatitis, yet a massive infiltration of lymphocytes and plasma cells is noted. B and D are magnified images of the yellow square in A and C, the black arrow shows the proliferation of interlobular bile ducts in the portal triad area (HE: C, × 100; D, × 200).