Yinhuang granule alleviates carbon tetrachloride-induced liver fibrosis in mice and its mechanism

Figure 4 Yinhuang granule ameliorated hepatic oxidative stress damage and inflammation induced by carbon tetrachloride in mice. A: Liver glutathione content (n = 6); B: Liver reactive oxygen species level (n = 6); C: Liver protein carbonylation content (n = 6); D: Liver superoxide dismutase activity (n = 5); E: Hepatic mRNA expression of tumour necrosis factor alpha, interleukin (IL)-1b, IL-6 and inducible nitric oxide synthase (n = 4-5). Data were expressed as mean ± SEM. ^aP < 0.05, ^bP < 0.01 vs control vehicle; ^cP < 0.05, ^dP < 0.01 vs carbon tetrachloride vehicle. CCl₄: Carbon tetrachloride; YHG: Yinhuang granule; GSH: Liver glutathione; ROS: Reactive oxygen species; SOD: Superoxide dismutase; TNF: Tumour necrosis factor; IL: Interleukin; iNOS: Inducible nitric oxide synthase.