Precision targeting in hepatocellular carcinoma: Exploring ligand-receptor mediated nanotherapy

doi:10.4254/wjh.v16.i2.164

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Feb 27, 2024 (publication date) through Feb 18, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Feb 27, 2024; 16(2): 164-176
Published online Feb 27, 2024. doi: 10.4254/wjh.v16.i2.164

Table 3 Summary of dual-targeted nanoformulations in hepatocellular carcinoma therapy

Ligand 1	Ligand 2	Nanocarrier	Payload	Particle size
Folic acid[100]	Lactobionic acid	Chitosan	5-Fu	163 ± 10 nm
Folic acid[101]	Lactobionic acid	Berberine; Diosmin	Casein micelles	Approximately 200 nm
Glycyrrhetinic acid[102]	Hyaluronic acid	Carbodiimide	Paclitaxe	200-320 nm
Lactobionic acid[103]	Glycyrrhetinic acid	Chitosan; Acrylic acid	DOX	Approximately 274 nm
Lactoferrin[104]	Lactobionic acid/Glycyrrhetinic acid	Phospholipid complex	Sorafenib; quercetin	169 ± 1.5; 230 ± 1.7
Biotin[105]	Lactobionic acid	PEG; PLGA	Curcumin 5-Fu	110-187 nm

5-Fu: 5-fluorouracil; DOX: Doxorubicin.

Citation: Zhou XQ, Li YP, Dang SS. Precision targeting in hepatocellular carcinoma: Exploring ligand-receptor mediated nanotherapy. World J Hepatol 2024; 16(2): 164-176
URL: https://www.wjgnet.com/1948-5182/full/v16/i2/164.htm
DOI: https://dx.doi.org/10.4254/wjh.v16.i2.164