Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma

Figure 4 Silencing of hypoxia-inducible factor-1α affected epithelial-mesenchymal transition in HepG2 cells (n = 6). A: E-cadherin and the relative ratio; B: Vimentin and the relative ratio; C: Snail and the relative ratio; D: Twist and the relative ratio; E: Hypoxia upregulated angiopoietin-2, promoting hepatocellular carcinoma progression. Ang-2: Angiopoietin-2; Con: Control group; Neg: Negative microRNA group; MiR: MicroRNA group; HRE: Hypoxia response element; EMT: Epithelial-mesenchymal transition; HBV: Hepatitis B virus; HIF-1α: Hypoxia-inducible factor-1α; HCC: Hepatocellular carcinoma. ^bP < 0.01, compared with the control group.