Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma

doi:10.4254/wjh.v16.i12.1480

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Dec 27, 2024; 16(12): 1480-1492
Published online Dec 27, 2024. doi: 10.4254/wjh.v16.i12.1480

Table 3 Dynamic alterations in angiopoietin-2 and hypoxia-inducible factor-1α during hepatocarcinogenesis in rats

Group	n	Ang-2		HIF-1α
Group	n	Liver (ng/mg)¹	Serum (μg/L)	Liver (ng/mg)¹	Serum (μg/L)
NC	12	69.7 ± 6.0	105.2 ± 19.2	9.7 ± 2.8	206.3 ± 9.6
HD	18	73.2 ± 17.0	140.2 ± 25.2	12.6 ± 3.2	270.2 ± 48.0
LC/PC	9	93.7 ± 11.2^a	203.8 ± 23.8^a	16.9 ± 2.6^b	401.6 ± 89.4^b
rHCC	9	107.6 ± 9. 8^b	222.4 ± 23.3^b	23.5 ± 8.9^b	445.9 ± 69.5^b

¹ng/per mg liver tissue.

^aP < 0.05, compared with the normal control group.

^bP < 0.01, compared with the normal control group.

Ang-2: Angiopoietin-2; HIF-lα: Hypoxia-inducible factor-1α; NC: Normal control; rHCC: Rat hepatocellular carcinoma; HD: Hepatocyte degeneration; LC: Liver cirrhosis; PC: Precancerosis.

Citation: Yang JL, Yang J, Fang RF, Sai WL, Yao DF, Yao M. Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma. World J Hepatol 2024; 16(12): 1480-1492
URL: https://www.wjgnet.com/1948-5182/full/v16/i12/1480.htm
DOI: https://dx.doi.org/10.4254/wjh.v16.i12.1480