Hypoxia upregulates hepatic angiopoietin-2 transcription to promote the progression of hepatocellular carcinoma

Table 2 Clinicopathological features associated with serum angiopoietin-2 levels in patients with hepatocellular carcinoma

Parameter	n	Ang-2 (mean ± SD, μg/L)	t value	P value
AFP (μg/L)			4.386	< 0.001
< 50	29	40.1 ± 8.1
≥ 50	51	45.2 ± 7.3
Portal vein invasion			10.11	< 0.001
With	49	48.2 ± 6.3
Without	31	39.4 ± 4.4
HBsAg			4.933	< 0.001
Negative	15	38.9 ± 6.1
Positive	65	45.8 ± 7.6
Tumor size			8.979	< 0.001
< 5 cm	38	40.3 ± 4.9
≥ 5 cm	42	48.7 ± 7.3
Liver cirrhosis			8.121	< 0.001
With	56	49.3 ± 6.1
Without	24	40.2 ± 8.4
Differentiation degree			9.408	< 0.001
Well/moderate	57	40.9 ± 4.1
Poor	23	48.7 ± 6.9
Gross classification			4.700	< 0.001
Unifocal	27	41.8 ± 6.3
Multifocal	53	47.7 ± 8.7
TNM			7.838	< 0.001
I-II	24	39.4 ± 4.9
III-IV	56	49.1 ± 8.5

AFP: Alpha-fetoprotein; Ang-2: Angiopoietin-2; HBsAg: Hepatitis B surface antigen; TNM: Tumor node metastasis.